Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients with Metabolic Syndrome

Angelo Maria Patti, Khalid Al-Rasadi, Niki Katsiki, Yajnavalka Banerjee, Dragana Nikolic, Luca Vanella, Rosaria Vincenza Giglio, Valeria Ausilia Giannone, Giuseppe Montalto, Manfredi Rizzo

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12 Citations (Scopus)


The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 ± 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 ± 13.5 to 79.4 ± 12.5 kg, P 2, P =.001), and waist circumference (from 105 ± 11 to 102 ± 10 cm, P =.0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P =.014) and total cholesterol (from 4.8 ± 1.4 to 4.5 ± 1.0 mmol/L, P =.03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.

Original languageEnglish
Pages (from-to)856-861
Number of pages6
Issue number9
Publication statusPublished - Oct 9 2015



  • chlorogenic acid
  • cholesterol
  • Curcuma longa
  • guggul
  • inulin
  • metabolic syndrome
  • natural supplement
  • oxidative stress
  • silymarin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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