TY - JOUR
T1 - Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients with Metabolic Syndrome
AU - Patti, Angelo Maria
AU - Al-Rasadi, Khalid
AU - Katsiki, Niki
AU - Banerjee, Yajnavalka
AU - Nikolic, Dragana
AU - Vanella, Luca
AU - Giglio, Rosaria Vincenza
AU - Giannone, Valeria Ausilia
AU - Montalto, Giuseppe
AU - Rizzo, Manfredi
N1 - Publisher Copyright:
© 2015 SAGE Publications.
PY - 2015/10/9
Y1 - 2015/10/9
N2 - The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 ± 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 ± 13.5 to 79.4 ± 12.5 kg, P <.0001), body mass index (from 29.6 [23.7] to 29.3 [21.9] kg/m2, P =.001), and waist circumference (from 105 ± 11 to 102 ± 10 cm, P =.0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P =.014) and total cholesterol (from 4.8 ± 1.4 to 4.5 ± 1.0 mmol/L, P =.03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.
AB - The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 ± 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 ± 13.5 to 79.4 ± 12.5 kg, P <.0001), body mass index (from 29.6 [23.7] to 29.3 [21.9] kg/m2, P =.001), and waist circumference (from 105 ± 11 to 102 ± 10 cm, P =.0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P =.014) and total cholesterol (from 4.8 ± 1.4 to 4.5 ± 1.0 mmol/L, P =.03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.
KW - Curcuma longa
KW - chlorogenic acid
KW - cholesterol
KW - guggul
KW - inulin
KW - metabolic syndrome
KW - natural supplement
KW - oxidative stress
KW - silymarin
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UR - http://www.scopus.com/inward/citedby.url?scp=84941116306&partnerID=8YFLogxK
U2 - 10.1177/0003319714568792
DO - 10.1177/0003319714568792
M3 - Article
C2 - 25632052
AN - SCOPUS:84941116306
SN - 0003-3197
VL - 66
SP - 856
EP - 861
JO - Angiology
JF - Angiology
IS - 9
ER -