Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection

G. Ryan, D. Klein, E. Knapp, M. J. Hosie, T. Grimes, M. J E M F Mabruk, O. Jarrett, J. J. Callanan

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Animal models of human immunodeficiency virus 1, such as feline immunodeficiency virus (FIV), provide the opportunities to dissect the mechanisms of early interactions of the virus with the central nervous system (CNS). The aims of the present study were to evaluate viral loads within CNS, cerebrospinal fluid (CSF), ocular fluid, and the plasma of cats in the first 23 weeks after intravenous inoculation with FIVGL8. Proviral loads were also determined within peripheral blood mononuclear cells (PBMCs) and brain tissue. In this acute phase of infection, virus entered the brain in the majority of animals. Virus distribution was initially in a random fashion, with more diffuse brain involvement as infection progressed. Virus in the CSF was predictive of brain parenchymal infection. While the peak of virus production in blood coincided with proliferation within brain, more sustained production appeared to continue in brain tissue. In contrast, proviral loads in the brain decreased to undetectable levels in the presence of a strengthening PBMC load. A final observation in this study was that there was no direct correlation between viral loads in regions of brain or ocular tissue and the presence of histopathology.

Original languageEnglish
Pages (from-to)7477-7485
Number of pages9
JournalJournal of Virology
Volume77
Issue number13
DOIs
Publication statusPublished - Jul 2003

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Feline Immunodeficiency Virus
Feline immunodeficiency virus
Felidae
Viral Load
central nervous system
Central Nervous System
cats
brain
Brain
Infection
infection
viruses
Viruses
cerebrospinal fluid
mononuclear leukocytes
viral load
Cerebrospinal Fluid
Blood Cells
eyes
Virus Diseases

ASJC Scopus subject areas

  • Immunology

Cite this

Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection. / Ryan, G.; Klein, D.; Knapp, E.; Hosie, M. J.; Grimes, T.; Mabruk, M. J E M F; Jarrett, O.; Callanan, J. J.

In: Journal of Virology, Vol. 77, No. 13, 07.2003, p. 7477-7485.

Research output: Contribution to journalArticle

Ryan, G. ; Klein, D. ; Knapp, E. ; Hosie, M. J. ; Grimes, T. ; Mabruk, M. J E M F ; Jarrett, O. ; Callanan, J. J. / Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection. In: Journal of Virology. 2003 ; Vol. 77, No. 13. pp. 7477-7485.
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