TY - GEN
T1 - Dynamics of coronavirus infection in human
AU - Rihan, Fathalla A.
AU - Al-Salti, Nasser S.
AU - Anwar, Mohamed Naim Y.
N1 - Publisher Copyright:
© 2018 Author(s).
PY - 2018/7/27
Y1 - 2018/7/27
N2 - Middle East Respiratory Syndrome Coronavirus (MERS-CorV), was discovered in humans with lower respiratory tract infection, causes a range of illnesses in humans, from the common cold to the Severe Acute Respiratory Syndrome (SARS). Scientists give much attention to study the CorV infection among groups and travelers. In this paper, we utilize a mathematical model governed by a system of differential equations, which incorporate target cell limitation and the innate interferon response, investigate the innate and adaptive immune responses to primary CorV infection in an individual. We also investigate the sensitivity analysis of the model to determine the most sensitive parameters and informative subintervals. This study may promote clearance of virus and host recovery from infection.
AB - Middle East Respiratory Syndrome Coronavirus (MERS-CorV), was discovered in humans with lower respiratory tract infection, causes a range of illnesses in humans, from the common cold to the Severe Acute Respiratory Syndrome (SARS). Scientists give much attention to study the CorV infection among groups and travelers. In this paper, we utilize a mathematical model governed by a system of differential equations, which incorporate target cell limitation and the innate interferon response, investigate the innate and adaptive immune responses to primary CorV infection in an individual. We also investigate the sensitivity analysis of the model to determine the most sensitive parameters and informative subintervals. This study may promote clearance of virus and host recovery from infection.
KW - Coronavirus
KW - Immunological barrier
KW - Infectious disease
KW - Mathematical modeling; Sensitivity
UR - http://www.scopus.com/inward/record.url?scp=85051112141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051112141&partnerID=8YFLogxK
U2 - 10.1063/1.5045415
DO - 10.1063/1.5045415
M3 - Conference contribution
AN - SCOPUS:85051112141
T3 - AIP Conference Proceedings
BT - Mathematical Methods and Computational Techniques in Science and Engineering II
A2 - Bardis, Nikos
PB - American Institute of Physics Inc.
T2 - 2nd International Conference on Mathematical Methods and Computational Techniques in Science and Engineering
Y2 - 16 February 2018 through 18 February 2018
ER -
