Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma

Anjum Othman; Shiyam Kumar; Asim Qureshi; Zabah M. Jawa; Ikram A. Burney

doi:10.1159/000528697

Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma

Anjum Othman^*, Shiyam Kumar, Asim Qureshi, Zabah M. Jawa, Ikram A. Burney

^*Corresponding author for this work

Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed through standard of care treatment for nonclear RCC. However, genetic analysis revealed a germline pathogenic variant of fumarate hydratase (FH) gene, and the patient had a sustained and durable response to pazopanib.

Original language	English
Pages (from-to)	240-248
Number of pages	9
Journal	Case Reports in Oncology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1159/000528697
Publication status	Published - Apr 14 2023

ASJC Scopus subject areas

Oncology

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AU - Jawa, Zabah M.

AU - Burney, Ikram A.

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AB - Tubulocystic carcinoma of the kidney (TC-RCC) is a rare renal tumor and has been recently included as a distinct entity in WHO classification of renal neoplasms. We report the case of a patient with metastatic tubulocystic RCC whose disease progressed through standard of care treatment for nonclear RCC. However, genetic analysis revealed a germline pathogenic variant of fumarate hydratase (FH) gene, and the patient had a sustained and durable response to pazopanib.

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Durable Response to Pazopanib in a Patient with Fumarate Hydratase-Mutant Tubulocystic Renal Cell Carcinoma

Abstract

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