Dual-function 2D cobalt metal-organic framework embedded on paper as a point-of-care diagnostic device: Application for the quantification of glucose

Haider A.J. Al Lawati*, Javad Hassanzadeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Point-of-care (POC) diagnostic devices play significant roles in delivering vital surveillance information and providing proper and timely care to patients. There is a challenge in the development of new diagnostic tools to overcome their current shortcomings in terms of cost issues, accuracy and performance. Herein, a highly efficient paper-based analytical device based on a 2D metal-organic framework (MOF) has been reported for the colorimetric/fluorometric monitoring of glucose. Because of the inherent bifunctional activity of cobalt-terephthalate MOF (CoMOF) nanosheets, great improvements were made to the stability and performance of glucose oxidase (GOX) and to its catalytic effect on the reaction of o-phenylenediamine (OPD) and H2O2. The exceptional behavior of 2D CoMOF, along with a precise smartphone readout, led to the rapid and sensitive colorimetric/fluorometric detection of glucose in biological samples. Paper modified by CoMOF and GOX was stable for a long time, and a yellow-brown color and a high fluorescence emission were observed after the addition of a low volume of sample and OPD solutions. The probe showed a wide linear effectiveness range of 50 μM-15 mM, with colorimetric and fluorometric detection limits of 16.3 and 3.2 μM, respectively. Despite its great simplicity, the developed probe showed high performance and accuracy for the quantification of glucose.

Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalAnalytica Chimica Acta
Volume1139
DOIs
Publication statusPublished - Dec 1 2020
Externally publishedYes

Keywords

  • Bifunctional metal-organic frameworks
  • Glucose
  • Paper-based diagnostic device
  • Smartphone

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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