Drug resistant Plasmodium falciparum in an area of seasonal transmission

Hamza A. Babiker, Gwiria Satti, Heather Ferguson, Riad Bayoumi, David Walliker

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Eastern Sudan lies at the edge of the malaria endemicity stratum, where transmission intensity is low and seasonal. The main malaria parasite in the region, Plasmodium falciparum, survives the long dry and transmission-free season as asymptomatic sub-patent infections, and resurges following annual rains. The short-lived annual transmission in this area precipitates cyclical malaria epidemics among the semi-immune inhabitants who resort to excessive anti-malarial drugs usage at this time of the year. Chloroquine resistance (CQR) first emerged in this area in the mid 1980s; however, subsequent surveys demonstrated that the rate of parasitological failure to CQ remained stable over a period of 8 years (1986-1993). Nevertheless, the CQR level varied between years in association with the amount of annual rain. Detailed molecular surveys revealed significant temporal fluctuations in the frequency of resistant P. falciparum genotypes, increasing during the dry season but dwindling at the start of the next transmission season. The pattern of spread of drug resistance in the area is discussed in the context of parasite biology and malaria epidemiology of this region.

Original languageEnglish
Pages (from-to)260-268
Number of pages9
JournalActa Tropica
Volume94
Issue number3 SPEC. ISS.
DOIs
Publication statusPublished - Jun 2005

Fingerprint

Plasmodium falciparum
malaria
Malaria
chloroquine
drugs
Rain
Chloroquine
Pharmaceutical Preparations
Parasites
rain
parasites
Sudan
antimalarials
Antimalarials
drug resistance
patents
Drug Resistance
epidemiology
dry season
Epidemiology

Keywords

  • Chloroquine resistance
  • Fitness cost
  • Genetic diversity
  • Plasmodium falciparum
  • Seasonal transmission

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Drug resistant Plasmodium falciparum in an area of seasonal transmission. / Babiker, Hamza A.; Satti, Gwiria; Ferguson, Heather; Bayoumi, Riad; Walliker, David.

In: Acta Tropica, Vol. 94, No. 3 SPEC. ISS., 06.2005, p. 260-268.

Research output: Contribution to journalArticle

Babiker, HA, Satti, G, Ferguson, H, Bayoumi, R & Walliker, D 2005, 'Drug resistant Plasmodium falciparum in an area of seasonal transmission', Acta Tropica, vol. 94, no. 3 SPEC. ISS., pp. 260-268. https://doi.org/10.1016/j.actatropica.2005.04.007
Babiker, Hamza A. ; Satti, Gwiria ; Ferguson, Heather ; Bayoumi, Riad ; Walliker, David. / Drug resistant Plasmodium falciparum in an area of seasonal transmission. In: Acta Tropica. 2005 ; Vol. 94, No. 3 SPEC. ISS. pp. 260-268.
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