Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

Hari K. Parthasarathy, Khamis Alhashmi, Alex D. McMahon, Allan D. Struthers, Gordon T. McInnes, Ian Ford, John M. Connell, Thomas M. MacDonald

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalJournal of Hypertension
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Aldosterone
Diuretics
Renin
Hypertension
Serum
Bendroflumethiazide
Mineralocorticoid Receptor Antagonists
Spironolactone
Cross-Over Studies
Antihypertensive Agents

Keywords

  • Aldosterone: renin ratio
  • Bendroflumethiazide
  • Plasma renin activity
  • Serum aldosterone
  • Spironolactone

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. / Parthasarathy, Hari K.; Alhashmi, Khamis; McMahon, Alex D.; Struthers, Allan D.; McInnes, Gordon T.; Ford, Ian; Connell, John M.; MacDonald, Thomas M.

In: Journal of Hypertension, Vol. 28, No. 1, 01.2010, p. 170-177.

Research output: Contribution to journal › Article

Parthasarathy, HK, Alhashmi, K, McMahon, AD, Struthers, AD, McInnes, GT, Ford, I, Connell, JM & MacDonald, TM 2010, 'Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO', Journal of Hypertension, vol. 28, no. 1, pp. 170-177. https://doi.org/10.1097/HJH.0b013e328332b79b
Parthasarathy HK, Alhashmi K, McMahon AD, Struthers AD, McInnes GT, Ford I et al. Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. Journal of Hypertension. 2010 Jan;28(1):170-177. https://doi.org/10.1097/HJH.0b013e328332b79b
Parthasarathy, Hari K. ; Alhashmi, Khamis ; McMahon, Alex D. ; Struthers, Allan D. ; McInnes, Gordon T. ; Ford, Ian ; Connell, John M. ; MacDonald, Thomas M. / Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. In: Journal of Hypertension. 2010 ; Vol. 28, No. 1. pp. 170-177.
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