TY - JOUR
T1 - Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO
AU - Parthasarathy, Hari K.
AU - Alhashmi, Khamis
AU - McMahon, Alex D.
AU - Struthers, Allan D.
AU - McInnes, Gordon T.
AU - Ford, Ian
AU - Connell, John M.
AU - MacDonald, Thomas M.
PY - 2010/1
Y1 - 2010/1
N2 - OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as
AB - OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as
KW - Aldosterone: renin ratio
KW - Bendroflumethiazide
KW - Plasma renin activity
KW - Serum aldosterone
KW - Spironolactone
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U2 - 10.1097/HJH.0b013e328332b79b
DO - 10.1097/HJH.0b013e328332b79b
M3 - Article
C2 - 20009770
AN - SCOPUS:73849092227
VL - 28
SP - 170
EP - 177
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
IS - 1
ER -