Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

Hari K. Parthasarathy; Khamis Alhashmi; Alex D. McMahon; Allan D. Struthers; Gordon T. McInnes; Ian Ford; John M. Connell; Thomas M. MacDonald

doi:10.1097/HJH.0b013e328332b79b

Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

Hari K. Parthasarathy, Khamis Alhashmi, Alex D. McMahon, Allan D. Struthers, Gordon T. McInnes, Ian Ford, John M. Connell, Thomas M. MacDonald

Physiology

Research output: Contribution to journal › Article

27 Citations (Scopus)

Abstract

OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

Original language	English
Pages (from-to)	170-177
Number of pages	8
Journal	Journal of Hypertension
Volume	28
Issue number	1
DOIs	https://doi.org/10.1097/HJH.0b013e328332b79b
Publication status	Published - Jan 2010

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Keywords

Aldosterone: renin ratio
Bendroflumethiazide
Plasma renin activity
Serum aldosterone
Spironolactone

ASJC Scopus subject areas

Internal Medicine
Physiology
Cardiology and Cardiovascular Medicine

Cite this

Parthasarathy, H. K., Alhashmi, K., McMahon, A. D., Struthers, A. D., McInnes, G. T., Ford, I., Connell, J. M., & MacDonald, T. M. (2010). Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. Journal of Hypertension, 28(1), 170-177. https://doi.org/10.1097/HJH.0b013e328332b79b

Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. / Parthasarathy, Hari K.; Alhashmi, Khamis; McMahon, Alex D.; Struthers, Allan D.; McInnes, Gordon T.; Ford, Ian; Connell, John M.; MacDonald, Thomas M.

In: Journal of Hypertension, Vol. 28, No. 1, 01.2010, p. 170-177.

Research output: Contribution to journal › Article

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10.1097/HJH.0b013e328332b79b