Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

Hari K. Parthasarathy, Khamis Alhashmi, Alex D. McMahon, Allan D. Struthers, Gordon T. McInnes, Ian Ford, John M. Connell, Thomas M. MacDonald

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalJournal of Hypertension
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2010

Fingerprint

Aldosterone
Diuretics
Renin
Hypertension
Serum
Bendroflumethiazide
Mineralocorticoid Receptor Antagonists
Spironolactone
Cross-Over Studies
Antihypertensive Agents

Keywords

  • Aldosterone: renin ratio
  • Bendroflumethiazide
  • Plasma renin activity
  • Serum aldosterone
  • Spironolactone

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. / Parthasarathy, Hari K.; Alhashmi, Khamis; McMahon, Alex D.; Struthers, Allan D.; McInnes, Gordon T.; Ford, Ian; Connell, John M.; MacDonald, Thomas M.

In: Journal of Hypertension, Vol. 28, No. 1, 01.2010, p. 170-177.

Research output: Contribution to journalArticle

Parthasarathy, Hari K. ; Alhashmi, Khamis ; McMahon, Alex D. ; Struthers, Allan D. ; McInnes, Gordon T. ; Ford, Ian ; Connell, John M. ; MacDonald, Thomas M. / Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. In: Journal of Hypertension. 2010 ; Vol. 28, No. 1. pp. 170-177.
@article{c3db877f99f7413eb6e1f6f0e44add14,
title = "Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO",
abstract = "OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as",
keywords = "Aldosterone: renin ratio, Bendroflumethiazide, Plasma renin activity, Serum aldosterone, Spironolactone",
author = "Parthasarathy, {Hari K.} and Khamis Alhashmi and McMahon, {Alex D.} and Struthers, {Allan D.} and McInnes, {Gordon T.} and Ian Ford and Connell, {John M.} and MacDonald, {Thomas M.}",
year = "2010",
month = "1",
doi = "10.1097/HJH.0b013e328332b79b",
language = "English",
volume = "28",
pages = "170--177",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

AU - Parthasarathy, Hari K.

AU - Alhashmi, Khamis

AU - McMahon, Alex D.

AU - Struthers, Allan D.

AU - McInnes, Gordon T.

AU - Ford, Ian

AU - Connell, John M.

AU - MacDonald, Thomas M.

PY - 2010/1

Y1 - 2010/1

N2 - OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

AB - OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

KW - Aldosterone: renin ratio

KW - Bendroflumethiazide

KW - Plasma renin activity

KW - Serum aldosterone

KW - Spironolactone

UR - http://www.scopus.com/inward/record.url?scp=73849092227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73849092227&partnerID=8YFLogxK

U2 - 10.1097/HJH.0b013e328332b79b

DO - 10.1097/HJH.0b013e328332b79b

M3 - Article

C2 - 20009770

AN - SCOPUS:73849092227

VL - 28

SP - 170

EP - 177

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 1

ER -