Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO

Hari K. Parthasarathy, Khamis Alhashmi, Alex D. McMahon, Allan D. Struthers, Gordon T. McInnes, Ian Ford, John M. Connell, Thomas M. MacDonald

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

OBJECTIVES: We hypothesized that the aldosterone: renin ratio (ARR) predicts the antihypertensive response to mineralocorticoid receptor antagonist, spironolactone (SPIRO), when compared with bendroflumethiazide (BFZ). METHODS: We conducted a randomized, crossover, trial on hypertensive patients with either high ARR (HARR defined as >750 and plasma aldosterone >250 pmol/l) or low ARR (LARR defined as

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalJournal of Hypertension
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Aldosterone: renin ratio
  • Bendroflumethiazide
  • Plasma renin activity
  • Serum aldosterone
  • Spironolactone

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Parthasarathy, H. K., Alhashmi, K., McMahon, A. D., Struthers, A. D., McInnes, G. T., Ford, I., Connell, J. M., & MacDonald, T. M. (2010). Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. Journal of Hypertension, 28(1), 170-177. https://doi.org/10.1097/HJH.0b013e328332b79b