Distribution of the lactase persistence-associated variant alleles-13910*T and-13915*G among the people of Oman and Yemen

Abdul Rahim Al-Abri, Omar Al-Rawas, Saeed Al-Yahyaee, Molham Al-Habori, Adel Sharaf Al-Zubairi, Riad Bayoumi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The high prevalence of lactase persistence (LP) among the people of Saudi Arabia is associated with the-13915*G variant allele upstream of the lactase gene (LCT). We, therefore, examined the frequency of the commonly known LP associated SNPs among randomly collected samples from Omani and Yemeni adult populations and obtained further data on the distribution of the two most common LP-associated variants,-13910*T and-13915T*G, in the Arabian Peninsula. The DNA fragment containing all the reported LP-associated SNPs was amplified and genotyped. The frequency of the-13915*G allele was highest among Dhofari Arabs of southern Oman (0.72) followed by Yemeni Arabs (0.54) and Arabs of northern Oman (0.14). It was not detected in Omanis of Asian origin. The frequency of the-13910*T allele was extremely low in Arabs of northern and southern Oman (0.00 0.01) and Yemenis (0.002). However, it had a frequency of 0.160 among Omanis of Asian origin. Results show that the highest frequency of the LCT-13915*G variant allele appears to be in the south of the Arabian Peninsula with clinal decrease within the Peninsula and further out in surrounding countries.

Original languageEnglish
Pages (from-to)271-286
Number of pages16
JournalHuman Biology
Volume84
Issue number3
Publication statusPublished - Jun 2012

Fingerprint

Yemen
Oman
Lactase
beta-galactosidase
Arabs
allele
persistence
Alleles
alleles
Single Nucleotide Polymorphism
gene
Saudi Arabia
DNA
Gene Frequency
distribution
genes
Population
Genes

Keywords

  • Arabian Peninsula
  • Lactase persistence
  • Oman
  • Yemen

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Ecology, Evolution, Behavior and Systematics

Cite this

Al-Abri, A. R., Al-Rawas, O., Al-Yahyaee, S., Al-Habori, M., Al-Zubairi, A. S., & Bayoumi, R. (2012). Distribution of the lactase persistence-associated variant alleles-13910*T and-13915*G among the people of Oman and Yemen. Human Biology, 84(3), 271-286.

Distribution of the lactase persistence-associated variant alleles-13910*T and-13915*G among the people of Oman and Yemen. / Al-Abri, Abdul Rahim; Al-Rawas, Omar; Al-Yahyaee, Saeed; Al-Habori, Molham; Al-Zubairi, Adel Sharaf; Bayoumi, Riad.

In: Human Biology, Vol. 84, No. 3, 06.2012, p. 271-286.

Research output: Contribution to journalArticle

Al-Abri, AR, Al-Rawas, O, Al-Yahyaee, S, Al-Habori, M, Al-Zubairi, AS & Bayoumi, R 2012, 'Distribution of the lactase persistence-associated variant alleles-13910*T and-13915*G among the people of Oman and Yemen', Human Biology, vol. 84, no. 3, pp. 271-286.
Al-Abri, Abdul Rahim ; Al-Rawas, Omar ; Al-Yahyaee, Saeed ; Al-Habori, Molham ; Al-Zubairi, Adel Sharaf ; Bayoumi, Riad. / Distribution of the lactase persistence-associated variant alleles-13910*T and-13915*G among the people of Oman and Yemen. In: Human Biology. 2012 ; Vol. 84, No. 3. pp. 271-286.
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