Distribution of arylamine n-acetyltransferase 2 (NAT2) genotypes among omanis

Musbah O.M. Tanira, Mehmet Simsek, Khalid Al Balushi, Khulood Al Lawatia, Hameedah Al Barawani, Riad A. Bayoumi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalSultan Qaboos University Medical Journal
Volume5
Issue number1-2
Publication statusPublished - Apr 1 2003

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Arylamine N-Acetyltransferase
Acetyltransferases
Alleles
Genotype
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction
Genes
N-acetyltalosaminuronic acid

Keywords

  • Genotyping
  • N-acetyltransferase (NAT)
  • Omani

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Distribution of arylamine n-acetyltransferase 2 (NAT2) genotypes among omanis. / Tanira, Musbah O.M.; Simsek, Mehmet; Al Balushi, Khalid; Al Lawatia, Khulood; Al Barawani, Hameedah; Bayoumi, Riad A.

In: Sultan Qaboos University Medical Journal, Vol. 5, No. 1-2, 01.04.2003, p. 9-14.

Research output: Contribution to journalArticle

Tanira, Musbah O.M. ; Simsek, Mehmet ; Al Balushi, Khalid ; Al Lawatia, Khulood ; Al Barawani, Hameedah ; Bayoumi, Riad A. / Distribution of arylamine n-acetyltransferase 2 (NAT2) genotypes among omanis. In: Sultan Qaboos University Medical Journal. 2003 ; Vol. 5, No. 1-2. pp. 9-14.
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AU - Al Balushi, Khalid

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AU - Al Barawani, Hameedah

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AB - Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.

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