Distribution of apolipoprotein E alleles in the Omani population

Said Ali S. Al-Yahyaee, Mohammed Nasser Al-Kindi, Ali Hassan Al-Bahrani

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalMedical Principles and Practice
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 2005

Fingerprint

Apolipoproteins E
Alleles
Gene Frequency
Population
Population Groups
Restriction Fragment Length Polymorphisms
Diet
Polymerase Chain Reaction

Keywords

  • Apolipoprotein E
  • DNA polymorphism
  • Dyslipidemia
  • Omani population
  • Population genetics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Distribution of apolipoprotein E alleles in the Omani population. / Al-Yahyaee, Said Ali S.; Al-Kindi, Mohammed Nasser; Al-Bahrani, Ali Hassan.

In: Medical Principles and Practice, Vol. 14, No. 2, 03.2005, p. 73-78.

Research output: Contribution to journalArticle

Al-Yahyaee, Said Ali S. ; Al-Kindi, Mohammed Nasser ; Al-Bahrani, Ali Hassan. / Distribution of apolipoprotein E alleles in the Omani population. In: Medical Principles and Practice. 2005 ; Vol. 14, No. 2. pp. 73-78.
@article{37a5aa0c6a2e427bb33a2215ac8b837b,
title = "Distribution of apolipoprotein E alleles in the Omani population",
abstract = "Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.",
keywords = "Apolipoprotein E, DNA polymorphism, Dyslipidemia, Omani population, Population genetics",
author = "Al-Yahyaee, {Said Ali S.} and Al-Kindi, {Mohammed Nasser} and Al-Bahrani, {Ali Hassan}",
year = "2005",
month = "3",
doi = "10.1159/000083914",
language = "English",
volume = "14",
pages = "73--78",
journal = "Medical Principles and Practice",
issn = "1011-7571",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Distribution of apolipoprotein E alleles in the Omani population

AU - Al-Yahyaee, Said Ali S.

AU - Al-Kindi, Mohammed Nasser

AU - Al-Bahrani, Ali Hassan

PY - 2005/3

Y1 - 2005/3

N2 - Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.

AB - Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.

KW - Apolipoprotein E

KW - DNA polymorphism

KW - Dyslipidemia

KW - Omani population

KW - Population genetics

UR - http://www.scopus.com/inward/record.url?scp=17244380203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17244380203&partnerID=8YFLogxK

U2 - 10.1159/000083914

DO - 10.1159/000083914

M3 - Article

VL - 14

SP - 73

EP - 78

JO - Medical Principles and Practice

JF - Medical Principles and Practice

SN - 1011-7571

IS - 2

ER -