TY - JOUR
T1 - Distribution of apolipoprotein E alleles in the Omani population
AU - Al-Yahyaee, Said Ali S.
AU - Al-Kindi, Mohammed Nasser
AU - Al-Bahrani, Ali Hassan
PY - 2005/3
Y1 - 2005/3
N2 - Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.
AB - Objective: To estimate the apolipoprotein E (apo E) allele distribution in the Omani population and to compare them with those of other populations. Subjects and Methods: One hundred and sixty-two healthy Omanis of Arab Bedouin origin were genotyped by polymerase chain reaction followed by restriction fragment length polymorphism. Results: The apo E allele frequencies were ε2, 0.052; ε3, 0.886; ε4, 0.062. This pattern of distribution, characterized by the lowest ε4 and among the highest ε3 allele frequencies in the world, was very similar to that of Arabs, Southern Europeans of the Mediterranean basin, Indians, and Japanese populations. Conclusion: The results indicate that the allelic distribution of apo E in healthy Omanis is characterized by low Apo ε4 and high ε3 allele frequencies similar to those of other Arab, Southern European, Japanese and Indian populations. The homogeneous distribution of apo E alleles in this group of populations might have been influenced by diet and/or genetic admixture.
KW - Apolipoprotein E
KW - DNA polymorphism
KW - Dyslipidemia
KW - Omani population
KW - Population genetics
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U2 - 10.1159/000083914
DO - 10.1159/000083914
M3 - Article
C2 - 15785096
AN - SCOPUS:17244380203
SN - 1011-7571
VL - 14
SP - 73
EP - 78
JO - Medical Principles and Practice
JF - Medical Principles and Practice
IS - 2
ER -