Differential K+ channel distribution in smooth muscle cells isolated from the pulmonary arterial tree of the rat

Sulayma Albarwani, Gideon Heinert, Joanne L. Turner, Roland Z. Kozlowski

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Intracellular photorelease of Ca2+ demonstrated the presence of Ca2+-activated K+ channels in smooth muscle cells isolated from different locations of the rat pulmonary arterial tree. However, cell-free patch studies revealed marked differences in K+ channel distribution. In the main pulmonary artery the most frequently observed K+ channel was a ~245pS conductance Ca2+- and ATP-activated (K(Ca),ATP) channel. In small pulmonary arteries two K+ channel types predominated: the K(Ca),ATP channel and a ~185pS conductance K+ channel insensitive to intracellular Ca2+, ATP and voltage. This difference in K+ channel distribution may highlight a more complex regulatory mechanism for controlling membrane potential in small pulmonary arteries,reflecting their physiologically more important role in governing pulmonary vascular reactivity.

Original languageEnglish
Pages (from-to)183-189
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume208
Issue number1
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Cell Biology

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