Differential involvement of the dentate gyrus in adaptive forgetting in the rat

Mickaël Antoine Joseph, Nicolas Fraize, Jennifer Ansoud-Lerouge, Emilie Sapin, Christelle Peyron, Sébastien Arthaud, Paul Antoine Libourel, Régis Parmentier, Paul Antoine Salin, Gaël Malleret

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

How does the brain discriminate essential information aimed to be stored permanently from information required only temporarily, and that needs to be cleared away for not saturating our precious memory space? Reference Memory (RM) refers to the long-term storage of invariable information whereas Working Memory (WM) depends on the short-term storage of trial-unique information. Previous work has revealed that WM tasks are very sensitive to proactive interference. In order to prevent such interference, irrelevant old memories must be forgotten to give new ones the opportunity to be stabilized. However, unlike memory, physiological processes underlying this adaptive form of forgetting are still poorly understood. Here, we precisely ask what specific brain structure(s) could be responsible for such process to occur. To answer this question, we trained rats in a radial maze using three paradigms, a RM task and two WM tasks involving or not the processing of interference but strictly identical in terms of locomotion or motivation. We showed that an inhibition of the expression of Zif268 and c-Fos, two indirect markers of neuronal activity and synaptic plasticity, was observed in the dentate gyrus of the dorsal hippocampus when processing such interfering previously stored information. Conversely, we showed that inactivating the dentate gyrus impairs both RM and WM, but improves the processing of interference. Altogether, these results strongly suggest for the first time that the dentate gyrus could be a key structure involved in adaptive forgetting.

Original languageEnglish
Article numbere0142065
JournalPLoS One
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 3 2015

Fingerprint

Dentate Gyrus
Rats
Short-Term Memory
Data storage equipment
rats
Neuronal Plasticity
Physiological Phenomena
Parahippocampal Gyrus
Information Storage and Retrieval
Brain
Locomotion
Motivation
Processing
brain
hippocampus
locomotion
Plasticity

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Joseph, M. A., Fraize, N., Ansoud-Lerouge, J., Sapin, E., Peyron, C., Arthaud, S., ... Malleret, G. (2015). Differential involvement of the dentate gyrus in adaptive forgetting in the rat. PLoS One, 10(11), [e0142065]. https://doi.org/10.1371/journal.pone.0142065

Differential involvement of the dentate gyrus in adaptive forgetting in the rat. / Joseph, Mickaël Antoine; Fraize, Nicolas; Ansoud-Lerouge, Jennifer; Sapin, Emilie; Peyron, Christelle; Arthaud, Sébastien; Libourel, Paul Antoine; Parmentier, Régis; Salin, Paul Antoine; Malleret, Gaël.

In: PLoS One, Vol. 10, No. 11, e0142065, 03.11.2015.

Research output: Contribution to journalArticle

Joseph, MA, Fraize, N, Ansoud-Lerouge, J, Sapin, E, Peyron, C, Arthaud, S, Libourel, PA, Parmentier, R, Salin, PA & Malleret, G 2015, 'Differential involvement of the dentate gyrus in adaptive forgetting in the rat', PLoS One, vol. 10, no. 11, e0142065. https://doi.org/10.1371/journal.pone.0142065
Joseph MA, Fraize N, Ansoud-Lerouge J, Sapin E, Peyron C, Arthaud S et al. Differential involvement of the dentate gyrus in adaptive forgetting in the rat. PLoS One. 2015 Nov 3;10(11). e0142065. https://doi.org/10.1371/journal.pone.0142065
Joseph, Mickaël Antoine ; Fraize, Nicolas ; Ansoud-Lerouge, Jennifer ; Sapin, Emilie ; Peyron, Christelle ; Arthaud, Sébastien ; Libourel, Paul Antoine ; Parmentier, Régis ; Salin, Paul Antoine ; Malleret, Gaël. / Differential involvement of the dentate gyrus in adaptive forgetting in the rat. In: PLoS One. 2015 ; Vol. 10, No. 11.
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