TY - JOUR
T1 - Differential glomerular filtration rate in diagnosis of renovascular hypertension and follow-up of balloon angioplasty
AU - Lamki, L.
AU - Spence, J. D.
AU - MacDonald, A. C.
AU - Roulston, M.
PY - 1986
Y1 - 1986
N2 - Two hundred and nine hypertensive patients with high stimulated plasma renin levels were screened for renovascular hypertension using Tc-99m DTPA renal scintigraphy. Differential glomerular filtration rate (Diff-GFR) was obtained by integrating the area under the background-subtracted renogram of each kidney between 1 and 3 minutes. 50 patients who also had undergone selective renal angiography were divided into four groups according to Diff-GFR contribution by one of the kidneys. If one kidney contributed 45-50% of total GFR, this was regarded as normal. A Diff-GFR of less than 45% was very considered to be very suggestive of renovascular hypertension in the appropriate clinical setting, while a Diff-GFR of less than 20% indicated that the renal artery might not be amenable to successful balloon angioplasty. Diff-GFR following balloon angioplasty closely reflected the early clinical response of the patients - and in some cases progressive Diff-GFR improvememt was observed several months later. Diff-GFR as a scintigraphic criterion for renovascular hypertension has a sensitivity of 93%, specificity of 74%, and accuracy of 85%.
AB - Two hundred and nine hypertensive patients with high stimulated plasma renin levels were screened for renovascular hypertension using Tc-99m DTPA renal scintigraphy. Differential glomerular filtration rate (Diff-GFR) was obtained by integrating the area under the background-subtracted renogram of each kidney between 1 and 3 minutes. 50 patients who also had undergone selective renal angiography were divided into four groups according to Diff-GFR contribution by one of the kidneys. If one kidney contributed 45-50% of total GFR, this was regarded as normal. A Diff-GFR of less than 45% was very considered to be very suggestive of renovascular hypertension in the appropriate clinical setting, while a Diff-GFR of less than 20% indicated that the renal artery might not be amenable to successful balloon angioplasty. Diff-GFR following balloon angioplasty closely reflected the early clinical response of the patients - and in some cases progressive Diff-GFR improvememt was observed several months later. Diff-GFR as a scintigraphic criterion for renovascular hypertension has a sensitivity of 93%, specificity of 74%, and accuracy of 85%.
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U2 - 10.1097/00003072-198603000-00012
DO - 10.1097/00003072-198603000-00012
M3 - Article
C2 - 2937597
AN - SCOPUS:0022650631
SN - 0363-9762
VL - 11
SP - 188
EP - 193
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 3
ER -