Abstract
Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P
Original language | English |
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Article number | 163902 |
Journal | Journal of Biomedicine and Biotechnology |
Volume | 2008 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 |
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
- Applied Microbiology and Biotechnology
- Medicine(all)