Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells

Dayanand D. Deo, Ashwin P. Rao, Saideep S. Bose, Allal Ouhtit, Surendra B. Baliga, Shilpa A. Rao, Bruce J. Trock, Rajesh Thouta, Madhwa H G Raj, Prakash N. Rao

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P

Original languageEnglish
Article number163902
JournalJournal of Biomedicine and Biotechnology
Volume2008
Issue number1
DOIs
Publication statusPublished - 2008

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Leptin
Androgens
Prostate
Cells
Carcinoma
Poisons
Obesity
Reactive Oxygen Species
Cytokines
Adipocytes
Energy Metabolism
Free Radicals
Prostatic Neoplasms
Homeostasis
Eating
Body Weight

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Applied Microbiology and Biotechnology
  • Medicine(all)

Cite this

Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. / Deo, Dayanand D.; Rao, Ashwin P.; Bose, Saideep S.; Ouhtit, Allal; Baliga, Surendra B.; Rao, Shilpa A.; Trock, Bruce J.; Thouta, Rajesh; Raj, Madhwa H G; Rao, Prakash N.

In: Journal of Biomedicine and Biotechnology, Vol. 2008, No. 1, 163902, 2008.

Research output: Contribution to journalArticle

Deo, DD, Rao, AP, Bose, SS, Ouhtit, A, Baliga, SB, Rao, SA, Trock, BJ, Thouta, R, Raj, MHG & Rao, PN 2008, 'Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells', Journal of Biomedicine and Biotechnology, vol. 2008, no. 1, 163902. https://doi.org/10.1155/2008/163902
Deo, Dayanand D. ; Rao, Ashwin P. ; Bose, Saideep S. ; Ouhtit, Allal ; Baliga, Surendra B. ; Rao, Shilpa A. ; Trock, Bruce J. ; Thouta, Rajesh ; Raj, Madhwa H G ; Rao, Prakash N. / Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. In: Journal of Biomedicine and Biotechnology. 2008 ; Vol. 2008, No. 1.
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