Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells

Dayanand D. Deo, Ashwin P. Rao, Saideep S. Bose, Allal Ouhtit, Surendra B. Baliga, Shilpa A. Rao, Bruce J. Trock, Rajesh Thouta, Madhwa H G Raj, Prakash N. Rao

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Abstract

Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P

Original languageEnglish
Article number163902
JournalJournal of Biomedicine and Biotechnology
Volume2008
Issue number1
DOIs
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Genetics
  • Applied Microbiology and Biotechnology
  • Medicine(all)

Cite this

Deo, D. D., Rao, A. P., Bose, S. S., Ouhtit, A., Baliga, S. B., Rao, S. A., Trock, B. J., Thouta, R., Raj, M. H. G., & Rao, P. N. (2008). Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. Journal of Biomedicine and Biotechnology, 2008(1), [163902]. https://doi.org/10.1155/2008/163902