Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells

Dayanand D. Deo; Ashwin P. Rao; Saideep S. Bose; Allal Ouhtit; Surendra B. Baliga; Shilpa A. Rao; Bruce J. Trock; Rajesh Thouta; Madhwa H G Raj; Prakash N. Rao

doi:10.1155/2008/163902

Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells

Dayanand D. Deo, Ashwin P. Rao, Saideep S. Bose, Allal Ouhtit, Surendra B. Baliga, Shilpa A. Rao, Bruce J. Trock, Rajesh Thouta, Madhwa H G Raj, Prakash N. Rao

Genetics

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P

Original language	English
Article number	163902
Journal	Journal of Biomedicine and Biotechnology
Volume	2008
Issue number	1
DOIs	https://doi.org/10.1155/2008/163902
Publication status	Published - 2008

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Genetics
Applied Microbiology and Biotechnology
Medicine(all)

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Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. / Deo, Dayanand D.; Rao, Ashwin P.; Bose, Saideep S.; Ouhtit, Allal; Baliga, Surendra B.; Rao, Shilpa A.; Trock, Bruce J.; Thouta, Rajesh; Raj, Madhwa H G; Rao, Prakash N.

In: Journal of Biomedicine and Biotechnology, Vol. 2008, No. 1, 163902, 2008.

Research output: Contribution to journal › Article › peer-review

Deo, Dayanand D. ; Rao, Ashwin P. ; Bose, Saideep S. ; Ouhtit, Allal ; Baliga, Surendra B. ; Rao, Shilpa A. ; Trock, Bruce J. ; Thouta, Rajesh ; Raj, Madhwa H G ; Rao, Prakash N. / Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. In: Journal of Biomedicine and Biotechnology. 2008 ; Vol. 2008, No. 1.

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