Abstract
Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P
| Original language | English |
|---|---|
| Article number | 163902 |
| Journal | Journal of Biomedicine and Biotechnology |
| Volume | 2008 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2008 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Genetics
- Applied Microbiology and Biotechnology
- Medicine(all)
Cite this
Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells. / Deo, Dayanand D.; Rao, Ashwin P.; Bose, Saideep S.; Ouhtit, Allal; Baliga, Surendra B.; Rao, Shilpa A.; Trock, Bruce J.; Thouta, Rajesh; Raj, Madhwa H G; Rao, Prakash N.
In: Journal of Biomedicine and Biotechnology, Vol. 2008, No. 1, 163902, 2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of leptin on the invasive potential of androgen-dependent and -independent prostate carcinoma cells
AU - Deo, Dayanand D.
AU - Rao, Ashwin P.
AU - Bose, Saideep S.
AU - Ouhtit, Allal
AU - Baliga, Surendra B.
AU - Rao, Shilpa A.
AU - Trock, Bruce J.
AU - Thouta, Rajesh
AU - Raj, Madhwa H G
AU - Rao, Prakash N.
PY - 2008
Y1 - 2008
N2 - Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P
AB - Obesity has been linked with an increased risk of prostate cancer. The formation of toxic free oxygen radicals has been implicated in obesity mediated disease processes. Leptin is one of the major cytokines produced by adipocytes and controls body weight homeostasis through food intake and energy expenditure. The rationale of the study was to determine the impact of leptin on the metastatic potential of androgen-sensitive (LNCaP) cells as well as androgen-insensitive (PC-3 and DU-145) cells. At a concentration of 200_nm, LNCaP cells showed a significant increase (20% above control; P
UR - http://www.scopus.com/inward/record.url?scp=47749149902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47749149902&partnerID=8YFLogxK
U2 - 10.1155/2008/163902
DO - 10.1155/2008/163902
M3 - Article
C2 - 18584049
AN - SCOPUS:47749149902
VL - 2008
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
IS - 1
M1 - 163902
ER -