Dietary Supplementation of Walnut Partially Reverses 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Neurodegeneration in a Mouse Model of Parkinson’s Disease

Musthafa Mohamed Essa, Selvaraju Subash, Chinnasamy Dhanalakshmi, Thamilarasan Manivasagam, Samir Al-Adawi, Gilles J. Guillemin, Arokiasamy Justin Thenmozhi

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14 Citations (Scopus)


Numerous studies indicating that natural plant sources and their active phytochemicals offer protection to the pathological processes related to the development of neurogenerative diseases including Parkinson’s disease (PD). In the present study, the neuro protective efficacy of dietary supplementation of walnut (6 %) for 28 days was examined in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (i.p., 20 mg/kg body weight/day) for last four consecutive days. MPTP injection diminished the levels of GSH, dopamine and metabolites along with decreased activities of GPx and mitochondrial complex I. Further, the levels of TBARS and enzymatic antioxidants such as SOD and catalase, MAO-B activities were enhanced by MPTP treatment. Behavioral deficits and lowered TH expression are also proved MPTP induced neurotoxicity. Dietary supplementation of walnut attenuated MPTP-induced impairment in PD mice might be by its MAO-B inhibitory, antioxidant and mitochondrial protective actions. To find out the exact mechanism of action walnut on PD mice warrants further extensive studies.

Original languageEnglish
Pages (from-to)1283-1293
Number of pages11
JournalNeurochemical Research
Issue number6
Publication statusPublished - May 6 2015



  • Antioxidants
  • Dopamine
  • Oxidative stress
  • Parkinson’s disease
  • Walnut

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Biochemistry

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