Abstract
Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P
| Original language | English |
|---|---|
| Pages (from-to) | 1517-1526 |
| Number of pages | 10 |
| Journal | Cellular Physiology and Biochemistry |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 |
Fingerprint
Keywords
- Air Pollution
- Emodin
- Heart
- Inflammation
- Particulate matter
- Thrombosis
ASJC Scopus subject areas
- Physiology
Cite this
Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. / Nemmar, Abderrahim; Al Dhaheri, Rauda; Alamiri, Jawaher; Al Hefeiti, Suhaila; Al Saedi, Hajar; Beegam, Sumaya; Yuvaraju, Priya; Yasin, Javed; Ali, Badreldin H.
In: Cellular Physiology and Biochemistry, Vol. 36, No. 4, 2015, p. 1517-1526.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice
T2 - Ameliorative Effect of Emodin
AU - Nemmar, Abderrahim
AU - Al Dhaheri, Rauda
AU - Alamiri, Jawaher
AU - Al Hefeiti, Suhaila
AU - Al Saedi, Hajar
AU - Beegam, Sumaya
AU - Yuvaraju, Priya
AU - Yasin, Javed
AU - Ali, Badreldin H.
PY - 2015
Y1 - 2015
N2 - Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P
AB - Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P
KW - Air Pollution
KW - Emodin
KW - Heart
KW - Inflammation
KW - Particulate matter
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=84936971383&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84936971383&partnerID=8YFLogxK
U2 - 10.1159/000430315
DO - 10.1159/000430315
M3 - Article
VL - 36
SP - 1517
EP - 1526
JO - Cellular Physiology and Biochemistry
JF - Cellular Physiology and Biochemistry
SN - 1015-8987
IS - 4
ER -