Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin

Abderrahim Nemmar, Rauda Al Dhaheri, Jawaher Alamiri, Suhaila Al Hefeiti, Hajar Al Saedi, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H. Ali

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19 Citations (Scopus)

Abstract

Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P

Original languageEnglish
Pages (from-to)1517-1526
Number of pages10
JournalCellular Physiology and Biochemistry
Volume36
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Air Pollution
  • Emodin
  • Heart
  • Inflammation
  • Particulate matter
  • Thrombosis

ASJC Scopus subject areas

  • Physiology

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    Nemmar, A., Al Dhaheri, R., Alamiri, J., Al Hefeiti, S., Al Saedi, H., Beegam, S., Yuvaraju, P., Yasin, J., & Ali, B. H. (2015). Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin. Cellular Physiology and Biochemistry, 36(4), 1517-1526. https://doi.org/10.1159/000430315