Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice

Ameliorative Effect of Emodin

Abderrahim Nemmar, Rauda Al Dhaheri, Jawaher Alamiri, Suhaila Al Hefeiti, Hajar Al Saedi, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H. Ali

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P

Original languageEnglish
Pages (from-to)1517-1526
Number of pages10
JournalCellular Physiology and Biochemistry
Volume36
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

Emodin
Vehicle Emissions
Blood Vessels
Homeostasis
Particulate Matter
Rheum
Plant Roots
Cardiovascular System
Oxidative Stress
Leukocytes
Anti-Inflammatory Agents
Antioxidants
Inflammation
Lung
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride

Keywords

  • Air Pollution
  • Emodin
  • Heart
  • Inflammation
  • Particulate matter
  • Thrombosis

ASJC Scopus subject areas

  • Physiology

Cite this

Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. / Nemmar, Abderrahim; Al Dhaheri, Rauda; Alamiri, Jawaher; Al Hefeiti, Suhaila; Al Saedi, Hajar; Beegam, Sumaya; Yuvaraju, Priya; Yasin, Javed; Ali, Badreldin H.

In: Cellular Physiology and Biochemistry, Vol. 36, No. 4, 2015, p. 1517-1526.

Research output: Contribution to journalArticle

Nemmar, A, Al Dhaheri, R, Alamiri, J, Al Hefeiti, S, Al Saedi, H, Beegam, S, Yuvaraju, P, Yasin, J & Ali, BH 2015, 'Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin', Cellular Physiology and Biochemistry, vol. 36, no. 4, pp. 1517-1526. https://doi.org/10.1159/000430315
Nemmar, Abderrahim ; Al Dhaheri, Rauda ; Alamiri, Jawaher ; Al Hefeiti, Suhaila ; Al Saedi, Hajar ; Beegam, Sumaya ; Yuvaraju, Priya ; Yasin, Javed ; Ali, Badreldin H. / Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. In: Cellular Physiology and Biochemistry. 2015 ; Vol. 36, No. 4. pp. 1517-1526.
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