Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin

Abderrahim Nemmar, Rauda Al Dhaheri, Jawaher Alamiri, Suhaila Al Hefeiti, Hajar Al Saedi, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H. Ali

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P

Original languageEnglish
Pages (from-to)1517-1526
Number of pages10
JournalCellular Physiology and Biochemistry
Volume36
Issue number4
DOIs
Publication statusPublished - 2015

Fingerprint

Emodin
Vehicle Emissions
Blood Vessels
Homeostasis
Particulate Matter
Rheum
Plant Roots
Cardiovascular System
Oxidative Stress
Leukocytes
Anti-Inflammatory Agents
Antioxidants
Inflammation
Lung
1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride

Keywords

  • Air Pollution
  • Emodin
  • Heart
  • Inflammation
  • Particulate matter
  • Thrombosis

ASJC Scopus subject areas

  • Physiology

Cite this

Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. / Nemmar, Abderrahim; Al Dhaheri, Rauda; Alamiri, Jawaher; Al Hefeiti, Suhaila; Al Saedi, Hajar; Beegam, Sumaya; Yuvaraju, Priya; Yasin, Javed; Ali, Badreldin H.

In: Cellular Physiology and Biochemistry, Vol. 36, No. 4, 2015, p. 1517-1526.

Research output: Contribution to journalArticle

Nemmar, A, Al Dhaheri, R, Alamiri, J, Al Hefeiti, S, Al Saedi, H, Beegam, S, Yuvaraju, P, Yasin, J & Ali, BH 2015, 'Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin', Cellular Physiology and Biochemistry, vol. 36, no. 4, pp. 1517-1526. https://doi.org/10.1159/000430315
Nemmar, Abderrahim ; Al Dhaheri, Rauda ; Alamiri, Jawaher ; Al Hefeiti, Suhaila ; Al Saedi, Hajar ; Beegam, Sumaya ; Yuvaraju, Priya ; Yasin, Javed ; Ali, Badreldin H. / Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. In: Cellular Physiology and Biochemistry. 2015 ; Vol. 36, No. 4. pp. 1517-1526.
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