Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin

Abderrahim Nemmar; Rauda Al Dhaheri; Jawaher Alamiri; Suhaila Al Hefeiti; Hajar Al Saedi; Sumaya Beegam; Priya Yuvaraju; Javed Yasin; Badreldin H. Ali

doi:10.1159/000430315

Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice: Ameliorative Effect of Emodin

Abderrahim Nemmar, Rauda Al Dhaheri, Jawaher Alamiri, Suhaila Al Hefeiti, Hajar Al Saedi, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H. Ali

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P

Original language	English
Pages (from-to)	1517-1526
Number of pages	10
Journal	Cellular Physiology and Biochemistry
Volume	36
Issue number	4
DOIs	https://doi.org/10.1159/000430315
Publication status	Published - 2015

Keywords

Air Pollution
Emodin
Heart
Inflammation
Particulate matter
Thrombosis

ASJC Scopus subject areas

Physiology

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10.1159/000430315

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Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. / Nemmar, Abderrahim; Al Dhaheri, Rauda; Alamiri, Jawaher; Al Hefeiti, Suhaila; Al Saedi, Hajar; Beegam, Sumaya; Yuvaraju, Priya; Yasin, Javed; Ali, Badreldin H.

In: Cellular Physiology and Biochemistry, Vol. 36, No. 4, 2015, p. 1517-1526.

Research output: Contribution to journal › Article › peer-review

Nemmar, Abderrahim ; Al Dhaheri, Rauda ; Alamiri, Jawaher ; Al Hefeiti, Suhaila ; Al Saedi, Hajar ; Beegam, Sumaya ; Yuvaraju, Priya ; Yasin, Javed ; Ali, Badreldin H. / Diesel Exhaust Particles Induce Impairment of Vascular and Cardiac Homeostasis in Mice : Ameliorative Effect of Emodin. In: Cellular Physiology and Biochemistry. 2015 ; Vol. 36, No. 4. pp. 1517-1526.

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abstract = "Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P",

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author = "Abderrahim Nemmar and {Al Dhaheri}, Rauda and Jawaher Alamiri and {Al Hefeiti}, Suhaila and {Al Saedi}, Hajar and Sumaya Beegam and Priya Yuvaraju and Javed Yasin and Ali, {Badreldin H.}",

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AU - Alamiri, Jawaher

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AU - Yasin, Javed

AU - Ali, Badreldin H.

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