Abstract
Background/Aim: There is strong epidemiological and clinical evidence that components of the cardiovascular system are adversely affected by particulate air pollutants through the generation of inflammation and oxidative stress. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), which is commonly found in the roots of rhubarb plant, has strong antioxidant and anti-inflammatory effects. However, its possible protective effect on the cardiovascular effect of particulate air pollutants has never been reported before. Methods: We tested, in Tuck-Ordinary mice, the possible ameliorative effect of emodin on the acute (24h) cardiovascular effects of diesel exhaust particles (DEP, 1 mg/kg) or saline (control). Emodin (4 mg/kg) was administered intraperitoneally 1h before and 7h after pulmonary exposure to DEP. Twenty four h following DEP exposure, several cardiovascular endpoints were assessed. Results: Emodin significantly prevented the increase of leukocyte (n=8, P
Original language | English |
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Pages (from-to) | 1517-1526 |
Number of pages | 10 |
Journal | Cellular Physiology and Biochemistry |
Volume | 36 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Air Pollution
- Emodin
- Heart
- Inflammation
- Particulate matter
- Thrombosis
ASJC Scopus subject areas
- Physiology