Diagnostic mr31/32000 Schistosoma mansoni proteins (sm31/32): Reaction with sera from Sudanese patients infected with S. mansoni or S. haematobium

Mohamed A. Idris, Andreas Ruppel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Sera of Sudanese patients with active infections of Schistosoma mansoni or S. haematobium were tested in immunoblots for their reactivity with Mr31/32 000 proteins of adult S. mansoni (Sm31/32). All sera from patients with intestinal (n=123) and all but one from those with urinary schistosomiasis (n=35) had antibodies against Sm31/32. These and additional data suggest that both specificity and sensitivity of Sm31/32 to detect schistosome infections are dose to 100%. Antibodies against these proteins developed also in monkeys after experimental infection with S. haematobium. Sm31/32 antigens reacted in immunoblots as a doublet with most S. haematobium-patient sera and as a broad band with many 5. mansoni-sera suggesting that at least two components are present in the molecular weight region of Mr31/32 000. The data demonstrate the potential use of Sm31/32 from adult worms to diagnose patients with intestinal or urinary schistosomiasis in endemic areas.

Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalJournal of Helminthology
Volume62
Issue number2
DOIs
Publication statusPublished - Jun 1988

Keywords

  • Schistosoma haematobium
  • Schistosoma mansoni
  • Sm31/32
  • diagnostic proteins
  • immunoblots
  • patient sera
  • serodiagnosis

ASJC Scopus subject areas

  • Parasitology
  • Animal Science and Zoology

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