Determination of ibuprofen in pharmaceutical formulations using time-resolved terbium-sensitized luminescence

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Abstract

A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were

Original languageEnglish
Pages (from-to)294-301
Number of pages8
JournalLuminescence
Volume22
Issue number4
DOIs
Publication statusPublished - Jul 2007

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Terbium
Drug Compounding
Ibuprofen
Luminescence
Pharmaceutical Preparations
Polysorbates
Surface-Active Agents
Limit of Detection
Buffers
trioctyl phosphine oxide

Keywords

  • Drug formulations
  • Ibuprofen
  • Sensitized luminescence
  • Terbium

ASJC Scopus subject areas

  • Biophysics

Cite this

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abstract = "A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were",
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N2 - A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were

AB - A sensitive and specific luminescence method for the determination of ibuprofen (IB) in pharmaceutical formulations in aqueous solution is described. The method is based on the luminescence sensitization of terbium (Tb 3+) by formation of ternary complex with IB in the presence of tri-n-octylphosphine oxide (TOPO) and Tween-20 as surfactant. The luminescence signal for Tb-IB-TOPO is monitored at λex = 229 nm and λcm = 545 nm. Optimum conditions for the formation of the complex in aqueous system, were 16 mmol/L TRIS buffer, pH 5.7, TOPO 200 umol/L and 15 μmol/L of Tb3+, which allows for the determination of 9.7 × 10-7 - 9.7 × 10-6 mol/L IB with a detection limit of 1.2 × 10-7 mol/L. The relative standard deviations of the method were

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