Determination of an aspergillus fumigatus-specific immunoglobulin G reference range in an adult Omani population

Munira Al-Rahman, Mahmood Al Kindi, Ibrahim Kutty, Ibrahim Al-Kalbani, Jalila Alshekaili

Research output: Contribution to journalArticle

Abstract

Objectives: The presence of abnormally high levels of Aspergillus fumigatus-specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic pulmonary aspergillosis. This study aimed to determine a reference range of A. fumigatus-specific IgG levels within a healthy adult Omani population. Methods: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. The sera of 125 healthy Omani blood donors were tested for A. fumigatus-specific IgG levels using an automated fluorescence enzyme immunoassay. Results: Initially, the data were not normally distributed; however, log transformation and the exclusion of four outliers resulted in an acceptable Gaussian distribution. The reference range was 2.0–68.7 mgA/L at the 2.5th and 97.5th percentiles, respectively, with 90% confidence intervals of 2.0–3.0 mgA/L and 48.0–76.0 mgA/L, respectively. Conclusion: The A. fumigatus-specific IgG reference range within a healthy adult Omani population was comparable to those reported in other populations.

Original languageEnglish
Pages (from-to)e43-e46
JournalSultan Qaboos University Medical Journal
Volume18
Issue number1
DOIs
Publication statusPublished - Feb 1 2018

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Keywords

  • Allergic bronchopulmonary aspergillosis
  • Aspergillus fumigatus
  • Immunoglobulin G
  • Oman
  • Pulmonary aspergillosis
  • Reference range

ASJC Scopus subject areas

  • Medicine(all)

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