Abstract
Epstein‐Barr virus (EBV) DNA was detected by in situ hybridization at 3 sites of 30 samples taken from clinically normal lateral border of tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10 controls. The first positive case showed a thin layer of parakeratosis correlated with positive signals for EBV in one area and an adjacent area without obvious parakeratosis was also positive for EBV. These findings were present on both sides of the tongue. The second case was unilaterally positive for EBV and parakeratosis was absent. The hybridization signals were localised to koilocyte‐like cells in the stratum spinosum, as in oral hairy leukoplakia (OHL). These observations suggest that the in situ hybridization technique can detect very early or subclinical OHL, and supports the role of EBV in the pathogenesis of this lesion.
| Original language | English |
|---|---|
| Pages (from-to) | 109-112 |
| Number of pages | 4 |
| Journal | Journal of Oral Pathology & Medicine |
| Volume | 24 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Epstein‐Barr virus
- hairy leukoplakia
- in situ hybridization
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Oral Surgery
- Otorhinolaryngology
- Cancer Research
- Periodontics
Cite this
Detection of Epstein‐Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia. / Mabruk, M. J.E.M.R.; Flint, S. R.; Toner, M.; Leonard, N.; Shells, O.; Coleman, D. C.; Atkins, G. J.
In: Journal of Oral Pathology & Medicine, Vol. 24, No. 3, 1995, p. 109-112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detection of Epstein‐Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia
AU - Mabruk, M. J.E.M.R.
AU - Flint, S. R.
AU - Toner, M.
AU - Leonard, N.
AU - Shells, O.
AU - Coleman, D. C.
AU - Atkins, G. J.
PY - 1995
Y1 - 1995
N2 - Epstein‐Barr virus (EBV) DNA was detected by in situ hybridization at 3 sites of 30 samples taken from clinically normal lateral border of tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10 controls. The first positive case showed a thin layer of parakeratosis correlated with positive signals for EBV in one area and an adjacent area without obvious parakeratosis was also positive for EBV. These findings were present on both sides of the tongue. The second case was unilaterally positive for EBV and parakeratosis was absent. The hybridization signals were localised to koilocyte‐like cells in the stratum spinosum, as in oral hairy leukoplakia (OHL). These observations suggest that the in situ hybridization technique can detect very early or subclinical OHL, and supports the role of EBV in the pathogenesis of this lesion.
AB - Epstein‐Barr virus (EBV) DNA was detected by in situ hybridization at 3 sites of 30 samples taken from clinically normal lateral border of tongue mucosa from 15 AIDS autopsies and in none of 20 samples from 10 controls. The first positive case showed a thin layer of parakeratosis correlated with positive signals for EBV in one area and an adjacent area without obvious parakeratosis was also positive for EBV. These findings were present on both sides of the tongue. The second case was unilaterally positive for EBV and parakeratosis was absent. The hybridization signals were localised to koilocyte‐like cells in the stratum spinosum, as in oral hairy leukoplakia (OHL). These observations suggest that the in situ hybridization technique can detect very early or subclinical OHL, and supports the role of EBV in the pathogenesis of this lesion.
KW - Epstein‐Barr virus
KW - hairy leukoplakia
KW - in situ hybridization
UR - http://www.scopus.com/inward/record.url?scp=0029257382&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029257382&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0714.1995.tb01149.x
DO - 10.1111/j.1600-0714.1995.tb01149.x
M3 - Article
C2 - 7776261
AN - SCOPUS:0029257382
VL - 24
SP - 109
EP - 112
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
SN - 0904-2512
IS - 3
ER -