Detection of Epstein-Barr virus in lower gastrointestinal tract lymphomas

A study in Malaysian patients

Asmah M. Yunos, Hasnan Jaafar, Fauziah M. Idris, Gurjeet Kaur, Mohamed J E M F Mabruk

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (GI) tract has not been fully elucidated. Aim: The aim of this study was to determine the presence and distribution of EBV in formalin-fixed paraffin-embedded tissue samples obtained from 18 Malaysian patients diagnosed with NHL of the lower GI tract. Methods: The GI tract lymphoma tissue samples analyzed for the presence of EBV were divided into the following groups: NHL of the small intestine (seven cases); NHL of the ileocecum (ten cases); and NHL of the rectum (one case). The presence of EBV-encoded RNA (EBER) in all of the above tissue samples was tested for using conventional in situ hybridization technology. Results: Two of 18 cases (11.1%) of NHL of the lower GI tract demonstrated positive signals for EBV/EBER. In the first positive case, EBV/EBER signals were located in lymphoma cells in the serosa layer of the small intestine. In the second EBV/EBER-positive case, EBV/EBER signals were detected in diffuse B-cell lymphoma of the ileocecum. Conclusion: These findings demonstrate a rare association between EBV and lower GI tract lymphomas in this group of Malaysian patients.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalMolecular Diagnosis and Therapy
Volume10
Issue number4
Publication statusPublished - 2006

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Lower Gastrointestinal Tract
Human Herpesvirus 4
Lymphoma
Non-Hodgkin's Lymphoma
RNA
Small Intestine
Serous Membrane
B-Cell Lymphoma

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Medicine(all)
  • Pharmacology

Cite this

Detection of Epstein-Barr virus in lower gastrointestinal tract lymphomas : A study in Malaysian patients. / Yunos, Asmah M.; Jaafar, Hasnan; Idris, Fauziah M.; Kaur, Gurjeet; Mabruk, Mohamed J E M F.

In: Molecular Diagnosis and Therapy, Vol. 10, No. 4, 2006, p. 251-256.

Research output: Contribution to journalArticle

Yunos, Asmah M. ; Jaafar, Hasnan ; Idris, Fauziah M. ; Kaur, Gurjeet ; Mabruk, Mohamed J E M F. / Detection of Epstein-Barr virus in lower gastrointestinal tract lymphomas : A study in Malaysian patients. In: Molecular Diagnosis and Therapy. 2006 ; Vol. 10, No. 4. pp. 251-256.
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