Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

Thuraya Al-Harthy; Wajdi M. Zoghaib; Raphael Stoll; Raid Abdel-Jalil

doi:10.1007/s00706-017-2088-4

Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

Thuraya Al-Harthy, Wajdi M. Zoghaib, Raphael Stoll, Raid Abdel-Jalil

Chemistry

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm³ compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	1-7
Number of pages	7
Journal	Monatshefte fur Chemie
DOIs	https://doi.org/10.1007/s00706-017-2088-4
Publication status	Accepted/In press - Jan 18 2018

Keywords

2-Arylbenzothiazole
Antimicrobial
Fluorine
Piperazine

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1007/s00706-017-2088-4

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Al-Harthy, T., Zoghaib, W. M., Stoll, R., & Abdel-Jalil, R. (Accepted/In press). Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties. Monatshefte fur Chemie, 1-7. https://doi.org/10.1007/s00706-017-2088-4

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AU - Stoll, Raphael

AU - Abdel-Jalil, Raid

PY - 2018/1/18

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N2 - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

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KW - Fluorine

KW - Piperazine

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