Abstract
Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]
| Original language | English |
|---|---|
| Pages (from-to) | 1-7 |
| Number of pages | 7 |
| Journal | Monatshefte fur Chemie |
| DOIs | |
| Publication status | Accepted/In press - Jan 18 2018 |
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Keywords
- 2-Arylbenzothiazole
- Antimicrobial
- Fluorine
- Piperazine
ASJC Scopus subject areas
- Chemistry(all)
Cite this
Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties. / Al-Harthy, Thuraya; Zoghaib, Wajdi M.; Stoll, Raphael; Abdel-Jalil, Raid.
In: Monatshefte fur Chemie, 18.01.2018, p. 1-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties
AU - Al-Harthy, Thuraya
AU - Zoghaib, Wajdi M.
AU - Stoll, Raphael
AU - Abdel-Jalil, Raid
PY - 2018/1/18
Y1 - 2018/1/18
N2 - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]
AB - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]
KW - 2-Arylbenzothiazole
KW - Antimicrobial
KW - Fluorine
KW - Piperazine
UR - http://www.scopus.com/inward/record.url?scp=85040778907&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040778907&partnerID=8YFLogxK
U2 - 10.1007/s00706-017-2088-4
DO - 10.1007/s00706-017-2088-4
M3 - Article
SP - 1
EP - 7
JO - Monatshefte fur Chemie
JF - Monatshefte fur Chemie
SN - 0026-9247
ER -