Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

Thuraya Al-Harthy, Wajdi M. Zoghaib, Raphael Stoll, Raid Abdel-Jalil

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalMonatshefte fur Chemie
DOIs
Publication statusAccepted/In press - Jan 18 2018

Fingerprint

Bearings (structural)
Fluorine
Bacteria
Thiazoles
Tamoxifen
Fungi
Molecules
piperazine

Keywords

  • 2-Arylbenzothiazole
  • Antimicrobial
  • Fluorine
  • Piperazine

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

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abstract = "Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]",
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T1 - Design, synthesis, and antimicrobial evaluation of novel 2-arylbenzothiazole analogs bearing fluorine and piperazine moieties

AU - Al-Harthy, Thuraya

AU - Zoghaib, Wajdi M.

AU - Stoll, Raphael

AU - Abdel-Jalil, Raid

PY - 2018/1/18

Y1 - 2018/1/18

N2 - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

AB - Abstract: The synthesis of a novel series of 5-fluoro-6-(4-methylpiperazin-1-yl)-substituted phenylbenzo[d]thiazoles is reported. These molecules have been screened against different bacteria and fungi strains. Among these, two compounds show excellent bacterial growth inhibition against Gram-positive bacteria Staphylococcus aureus with MIC 32 μg/cm3 compared to tamoxifen used as a positive standard. Graphical abstract: [Figure not available: see fulltext.]

KW - 2-Arylbenzothiazole

KW - Antimicrobial

KW - Fluorine

KW - Piperazine

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