Design and Synthesis of Benzothiazole Schiff Bases of Potential Antitumor Activity

Thuraya Al-Harthy; Raid Abdel-Jalil; Wajdi Zoghaib; Maren Pflüger; Elisabeth Hofmann; Harald Hundsberger

doi:10.3987/COM-16-13471

Design and Synthesis of Benzothiazole Schiff Bases of Potential Antitumor Activity

Thuraya Al-Harthy, Raid Abdel-Jalil, Wajdi Zoghaib, Maren Pflüger, Elisabeth Hofmann, Harald Hundsberger

Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

Original language	English
Pages (from-to)	1282-1292
Number of pages	11
Journal	Heterocycles
Volume	92
Issue number	7
DOIs	https://doi.org/10.3987/COM-16-13471
Publication status	Published - 2016

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Design and Synthesis of Benzothiazole Schiff Bases of Potential Antitumor Activity",

abstract = "In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.",

author = "Thuraya Al-Harthy and Raid Abdel-Jalil and Wajdi Zoghaib and Maren Pfl{\"u}ger and Elisabeth Hofmann and Harald Hundsberger",

note = "Publisher Copyright: {\textcopyright} 2016 The Japan Institute of Heterocyclic Chemistry Received.",

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AU - Al-Harthy, Thuraya

AU - Abdel-Jalil, Raid

AU - Zoghaib, Wajdi

AU - Pflüger, Maren

AU - Hofmann, Elisabeth

AU - Hundsberger, Harald

PY - 2016

Y1 - 2016

N2 - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

AB - In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

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JO - Heterocycles

JF - Heterocycles

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ER -

Design and Synthesis of Benzothiazole Schiff Bases of Potential Antitumor Activity

Abstract

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