Design and synthesis of benzothiazole schiff bases of potential antitumor activity

Thuraya Al-Harthy, Raid Abdel-Jalil, Wajdi Zoghaib, Maren Pflüger, Elisabeth Hofmann, Harald Hundsberger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

Original languageEnglish
Pages (from-to)1282-1292
Number of pages11
JournalHeterocycles
Volume92
Issue number7
DOIs
Publication statusPublished - 2016

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Pharmacology

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