Dendritic spines

Revisiting the physiological role

Saravana Babu Chidambaram, A. G. Rathipriya, Srinivasa Rao Bolla, Abid Bhat, Bipul Ray, Arehally Marappa Mahalakshmi, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Mohamed Musthafa Essa, Gilles J. Guillemin, Ramesh Chandra, Meena Kishore Sakharkar

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Dendritic spines are small, thin, specialized protrusions from neuronal dendrites, primarily localized in the excitatory synapses. Sophisticated imaging techniques revealed that dendritic spines are complex structures consisting of a dense network of cytoskeletal, transmembrane and scaffolding molecules, and numerous surface receptors. Molecular signaling pathways, mainly Rho and Ras family small GTPases pathways that converge on actin cytoskeleton, regulate the spine morphology and dynamics bi-directionally during synaptic activity. During synaptic plasticity the number and shapes of dendritic spines undergo radical reorganizations. Long-term potentiation (LTP) induction promote spine head enlargement and the formation and stabilization of new spines. Long-term depression (LTD) results in their shrinkage and retraction. Reports indicate increased spine density in the pyramidal neurons of autism and Fragile X syndrome patients and reduced density in the temporal gyrus loci of schizophrenic patients. Post-mortem reports of Alzheimer's brains showed reduced spine number in the hippocampus and cortex. This review highlights the spine morphogenesis process, the activity-dependent structural plasticity and mechanisms by which synaptic activity sculpts the dendritic spines, the structural and functional changes in spines during learning and memory using LTP and LTD processes. It also discusses on spine status in neurodegenerative diseases and the impact of nootropics and neuroprotective agents on the functional restoration of dendritic spines.

Original languageEnglish
Pages (from-to)161-193
Number of pages33
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume92
DOIs
Publication statusPublished - Jun 8 2019

Fingerprint

Dendritic Spines
Spine
Long-Term Potentiation
Depression
Nootropic Agents
Fragile X Syndrome
Neuronal Plasticity
Monomeric GTP-Binding Proteins
Pyramidal Cells
Neuroprotective Agents
Temporal Lobe
Autistic Disorder
Dendrites
Actin Cytoskeleton
Morphogenesis
Neurodegenerative Diseases
Synapses
Hippocampus
Learning
Brain

Keywords

  • Dendritic spine pathology
  • Dendritic spines
  • Neurological diseases
  • Spine dynamics
  • synaptic plasticity

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Chidambaram, S. B., Rathipriya, A. G., Bolla, S. R., Bhat, A., Ray, B., Mahalakshmi, A. M., ... Sakharkar, M. K. (2019). Dendritic spines: Revisiting the physiological role. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 92, 161-193. https://doi.org/10.1016/j.pnpbp.2019.01.005

Dendritic spines : Revisiting the physiological role. / Chidambaram, Saravana Babu; Rathipriya, A. G.; Bolla, Srinivasa Rao; Bhat, Abid; Ray, Bipul; Mahalakshmi, Arehally Marappa; Manivasagam, Thamilarasan; Thenmozhi, Arokiasamy Justin; Essa, Mohamed Musthafa; Guillemin, Gilles J.; Chandra, Ramesh; Sakharkar, Meena Kishore.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 92, 08.06.2019, p. 161-193.

Research output: Contribution to journalReview article

Chidambaram, SB, Rathipriya, AG, Bolla, SR, Bhat, A, Ray, B, Mahalakshmi, AM, Manivasagam, T, Thenmozhi, AJ, Essa, MM, Guillemin, GJ, Chandra, R & Sakharkar, MK 2019, 'Dendritic spines: Revisiting the physiological role', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 92, pp. 161-193. https://doi.org/10.1016/j.pnpbp.2019.01.005
Chidambaram SB, Rathipriya AG, Bolla SR, Bhat A, Ray B, Mahalakshmi AM et al. Dendritic spines: Revisiting the physiological role. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 Jun 8;92:161-193. https://doi.org/10.1016/j.pnpbp.2019.01.005
Chidambaram, Saravana Babu ; Rathipriya, A. G. ; Bolla, Srinivasa Rao ; Bhat, Abid ; Ray, Bipul ; Mahalakshmi, Arehally Marappa ; Manivasagam, Thamilarasan ; Thenmozhi, Arokiasamy Justin ; Essa, Mohamed Musthafa ; Guillemin, Gilles J. ; Chandra, Ramesh ; Sakharkar, Meena Kishore. / Dendritic spines : Revisiting the physiological role. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 ; Vol. 92. pp. 161-193.
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