Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in Parkinsonian rats

Muthu Ramkumar, Srinivasagam Rajasankar, Veerapan Venkatesh Gobi, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohamed Essa, Ranganathan Chidambaram, Saravana Babu Chidambaram, Giles J. Guillemin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder (NDD) associated with the loss of dopaminergic neurons in the substantia nigra and subsequently has an effect on motor function and coordination. The pathology of PD is multifactorial, in which neuroinflammation and oxidative damage are the two of the main protagonists. Objectives: The present study aims to assess the potential antioxidant and anti-inflammatory effects of demethoxycurcumin (DMC), a natural derivative of curcumin, against rotenone-induced PD in rats. Materials and Methods: Rats were randomized and divided into six groups: Control, rotenone (0.5 mg/kg/day, intraperitoneal in sunflower oil) treated for 7 days, rotenone and DMC (5, 10, and 20 mg/kg b.w) cotreated, and DMC (20 mg/kg b.w) alone treated groups. Results: Based on the dopamine concentration and biochemical estimations, the effective dose of DMC was selected and the chronic study was performed. At the end of the experimental period, behavioral studies and protein expression patterns of inflammatory markers were analyzed. Rotenone treatment led to motor dysfunctions, neurochemical deficits, and oxidative stress and enhanced expressions of inflammatory markers, whereas oral administration of DMC attenuated all the above. Conclusion: Even though further research is needed to prove its efficacy in clinical trial, the results of our study showed that DMC may offer a promising and new therapeutic lead for the treatment of NDDs including PD.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalPharmacognosy Magazine
Volume14
Issue number53
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Rotenone
Curcumin
Dopamine
Anti-Inflammatory Agents
Parkinson Disease
Dopaminergic Neurons
Substantia Nigra
Neurodegenerative Diseases
Oral Administration
demethoxycurcumin
Oxidative Stress
Therapeutics
Antioxidants
Clinical Trials
Pathology
Control Groups
Research
Proteins

Keywords

  • Demethoxycurcumin
  • dopamine
  • neurodegenerative disease
  • neuroinflammation
  • oxidative stress

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this

Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in Parkinsonian rats. / Ramkumar, Muthu; Rajasankar, Srinivasagam; Gobi, Veerapan Venkatesh; Janakiraman, Udaiyappan; Manivasagam, Thamilarasan; Thenmozhi, Arokiasamy Justin; Essa, Musthafa Mohamed; Chidambaram, Ranganathan; Chidambaram, Saravana Babu; Guillemin, Giles J.

In: Pharmacognosy Magazine, Vol. 14, No. 53, 01.01.2018, p. 9-16.

Research output: Contribution to journalArticle

Ramkumar, Muthu ; Rajasankar, Srinivasagam ; Gobi, Veerapan Venkatesh ; Janakiraman, Udaiyappan ; Manivasagam, Thamilarasan ; Thenmozhi, Arokiasamy Justin ; Essa, Musthafa Mohamed ; Chidambaram, Ranganathan ; Chidambaram, Saravana Babu ; Guillemin, Giles J. / Demethoxycurcumin, a natural derivative of curcumin abrogates rotenone-induced dopamine depletion and motor deficits by its antioxidative and anti-inflammatory properties in Parkinsonian rats. In: Pharmacognosy Magazine. 2018 ; Vol. 14, No. 53. pp. 9-16.
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AU - Rajasankar, Srinivasagam

AU - Gobi, Veerapan Venkatesh

AU - Janakiraman, Udaiyappan

AU - Manivasagam, Thamilarasan

AU - Thenmozhi, Arokiasamy Justin

AU - Essa, Musthafa Mohamed

AU - Chidambaram, Ranganathan

AU - Chidambaram, Saravana Babu

AU - Guillemin, Giles J.

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N2 - Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder (NDD) associated with the loss of dopaminergic neurons in the substantia nigra and subsequently has an effect on motor function and coordination. The pathology of PD is multifactorial, in which neuroinflammation and oxidative damage are the two of the main protagonists. Objectives: The present study aims to assess the potential antioxidant and anti-inflammatory effects of demethoxycurcumin (DMC), a natural derivative of curcumin, against rotenone-induced PD in rats. Materials and Methods: Rats were randomized and divided into six groups: Control, rotenone (0.5 mg/kg/day, intraperitoneal in sunflower oil) treated for 7 days, rotenone and DMC (5, 10, and 20 mg/kg b.w) cotreated, and DMC (20 mg/kg b.w) alone treated groups. Results: Based on the dopamine concentration and biochemical estimations, the effective dose of DMC was selected and the chronic study was performed. At the end of the experimental period, behavioral studies and protein expression patterns of inflammatory markers were analyzed. Rotenone treatment led to motor dysfunctions, neurochemical deficits, and oxidative stress and enhanced expressions of inflammatory markers, whereas oral administration of DMC attenuated all the above. Conclusion: Even though further research is needed to prove its efficacy in clinical trial, the results of our study showed that DMC may offer a promising and new therapeutic lead for the treatment of NDDs including PD.

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