Deferasirox (Exjade®) significantly improves cardiac T2* in heavily iron-overloaded patients with β-thalassemia major

Anil Pathare, Ali Taher, Shahina Daar

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Noninvasive measurement of tissue iron levels can be assessed using T2* magnetic resonance imaging (MRI) to identify and monitor patients with iron overload. This study monitored cardiac siderosis using T2* MRI in a cohort of 19 heavily iron-overloaded patients with β-thalassemia major receiving iron chelation therapy with deferasirox over an 18-month period. Overall, deferasirox therapy significantly improved mean ± standard deviation cardiac T2* from a baseline of 17.2±10.8 to 21.5±12.8 ms (+25.0%; P=0.02). A concomitant reduction in median serum ferritin from a baseline of 5,497 to 4,235 ng/mL (-23.0%; P=0.001), and mean liver iron concentration from 24.2±9.0 to 17.6± 12.9 mg Fe/g dry weight (-27.1%; P=0.01) was also seen. Improvements were seen in patients with various degrees of cardiac siderosis, including those patients with a baseline cardiac T2* of

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalAnnals of Hematology
Volume89
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • β-thalassemia
  • Iron chelation
  • Iron overload
  • Magnetic resonance imaging
  • Myocardial iron
  • T2*

ASJC Scopus subject areas

  • Hematology

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