Decreased levels of circulating IL-21 in HIV-infected AIDS patients: Correlation with CD4+ T-cell counts

Alexandre Iannello, Cecile Tremblay, Jean Pierre Routy, Mohamed Rachid Boulassel, Emil Toma, Ali Ahmad

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

IL-21 is a relatively newly discovered multifunctional and pleiotropic cytokine. It is produced primarily by CD4+ T cells, the principal targets of the virus, and therefore this cytokine has special relevance to HIV infection. Here we show for the first time that serum levels of this cytokine are significantly reduced in HIV-infected AIDS patients and correlate significantly with their CD4+ T-cell counts. These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS.

Original languageEnglish
Pages (from-to)385-388
Number of pages4
JournalViral Immunology
Volume21
Issue number3
DOIs
Publication statusPublished - Sep 1 2008

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CD4 Lymphocyte Count
Acquired Immunodeficiency Syndrome
HIV
Cytokines
T-Lymphocytes
HIV Infections
Biomarkers
Viruses
interleukin-21
Serum

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

Cite this

Decreased levels of circulating IL-21 in HIV-infected AIDS patients : Correlation with CD4+ T-cell counts. / Iannello, Alexandre; Tremblay, Cecile; Routy, Jean Pierre; Boulassel, Mohamed Rachid; Toma, Emil; Ahmad, Ali.

In: Viral Immunology, Vol. 21, No. 3, 01.09.2008, p. 385-388.

Research output: Contribution to journalArticle

Iannello, Alexandre ; Tremblay, Cecile ; Routy, Jean Pierre ; Boulassel, Mohamed Rachid ; Toma, Emil ; Ahmad, Ali. / Decreased levels of circulating IL-21 in HIV-infected AIDS patients : Correlation with CD4+ T-cell counts. In: Viral Immunology. 2008 ; Vol. 21, No. 3. pp. 385-388.
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