TY - JOUR
T1 - Decreased levels of circulating IL-21 in HIV-infected AIDS patients
T2 - Correlation with CD4+ T-cell counts
AU - Iannello, Alexandre
AU - Tremblay, Cecile
AU - Routy, Jean Pierre
AU - Boulassel, Mohamed Rachid
AU - Toma, Emil
AU - Ahmad, Ali
PY - 2008/9/1
Y1 - 2008/9/1
N2 - IL-21 is a relatively newly discovered multifunctional and pleiotropic cytokine. It is produced primarily by CD4+ T cells, the principal targets of the virus, and therefore this cytokine has special relevance to HIV infection. Here we show for the first time that serum levels of this cytokine are significantly reduced in HIV-infected AIDS patients and correlate significantly with their CD4+ T-cell counts. These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS.
AB - IL-21 is a relatively newly discovered multifunctional and pleiotropic cytokine. It is produced primarily by CD4+ T cells, the principal targets of the virus, and therefore this cytokine has special relevance to HIV infection. Here we show for the first time that serum levels of this cytokine are significantly reduced in HIV-infected AIDS patients and correlate significantly with their CD4+ T-cell counts. These data suggest that the cytokine levels could act as a valuable biomarker for the progression of AIDS.
UR - http://www.scopus.com/inward/record.url?scp=51849116934&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51849116934&partnerID=8YFLogxK
U2 - 10.1089/vim.2008.0025
DO - 10.1089/vim.2008.0025
M3 - Article
C2 - 18788946
AN - SCOPUS:51849116934
SN - 0882-8245
VL - 21
SP - 385
EP - 388
JO - Viral Immunology
JF - Viral Immunology
IS - 3
ER -
