De novo infantile primary antiphospholipid antibody syndrome

J. Alshekaili, G. Reynolds, M. C. Cook

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Most autoimmune diseases are rare in infants. Early onset can represent an extreme phenotype arising from strong genetic predisposition relatively independent of environmental influence. Alternatively, neonatal autoimmunity can arise from transplacental passage of maternal pathogenic IgG autoantibodies. Distinguishing between these possible explanations is crucial for determining the prognosis in the specific patient, and has important implications for understanding pathogenesis. We report a case of neonatal thrombotic stroke associated with both cardiolipin and β2-glycoprotein I antibodies in neonatal serum but absent from cord blood and maternal serum. While the child also carried one prothrombotic allele of factor V (Leiden allele), which may have contributed to the risk of thromboembolic disease, the serological analysis represents unequivocal evidence of de novo neonatal primary phospholipid antibody syndrome.

Original languageEnglish
Pages (from-to)1565-1568
Number of pages4
JournalLupus
Volume19
Issue number13
DOIs
Publication statusPublished - Nov 2010

Fingerprint

Antiphospholipid Syndrome
Alleles
Mothers
Cardiolipins
Antibodies
Genetic Predisposition to Disease
Serum
Autoimmunity
Fetal Blood
Autoantibodies
Autoimmune Diseases
Phospholipids
Glycoproteins
Immunoglobulin G
Stroke
Phenotype
factor V Leiden

Keywords

  • Anticardiolipin antibodies
  • antiphospholipid syndrome
  • pregnancy

ASJC Scopus subject areas

  • Rheumatology

Cite this

De novo infantile primary antiphospholipid antibody syndrome. / Alshekaili, J.; Reynolds, G.; Cook, M. C.

In: Lupus, Vol. 19, No. 13, 11.2010, p. 1565-1568.

Research output: Contribution to journalArticle

Alshekaili, J. ; Reynolds, G. ; Cook, M. C. / De novo infantile primary antiphospholipid antibody syndrome. In: Lupus. 2010 ; Vol. 19, No. 13. pp. 1565-1568.
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