Cytogenetic, morphological, and immunophenotypic patterns in Omani patients with de novo acute myeloid leukemia

Achandira Muthappa Udayakumar, Anil Vasant Pathare, Salam Al-Kindi, Hamad Khan, Jalil Ur Rehmen, Fehmida Zia, Asem Al-Ghazaly, Nadeem Nusrut, Muhammad Irfan Khan, Yasser Ahmed Wali, Zakia Al-Lamki, David Dennison, John Alexander Raeburn

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Abstract

Chromosome aberrations observed at diagnosis are considered to be the most valuable prognostic factors in acute myeloid leukemia (AML). Some specific aberrations vary in frequency among different geographical areas and ethnic groups. There are only limited studies on the role of such variability in AML patients. Here, we report the results of a cytogenetic study on 63 ethnic Omani patients with de novo AML: 18 children (≤16 years) and 45 adults. By sex, 41 were male and 22 female; median age at diagnosis was 25 years. The morphological diagnosis was based on the French-American-British (FAB) WHO criteria. Chromosome abnormalities were present in 39 of 63 patients (62% overall, or 44% for adults and 18% for children). Karyotypes with a sole abnormality accounted for 20 of 63 patients (32%). Chromosome abnormalities were more common in patients with the FAB-M2 subtype (15 of 22; 68%), which was also the most frequent subtype observed (22 of 63; 35%). Among the normal karyotypes (24 of 63; 38%), M2 subtype was the also most frequent (7 of 24; 29%), followed by M4 (4 of 24; 17%). Balanced translocations, t(8;21) and t(15;17) were observed in 7 of 63 (11%) and 6 of 63 (10%), respectively. Inv(16) was seen in 2 of 63 (3%). Trisomy 8 was the most frequent numerical anomaly, found in 7 of 63 (11%). Monosomy 7 was seen in 3 of 63 (5%). The patterns in our study were similar to those reported from Saudi Arabia and Kuwait, but the frequency of abnormalities varied. Our population differed morphologically, with the M2 subtype as most common, whereas M4 and M3 were more commonly in those reports. A comparison of our findings was made with other geographic and ethnic groups. This is the first systematic cytogenetic study of an ethnic Omani population.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume177
Issue number2
DOIs
Publication statusPublished - Sep 2007

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ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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