Cushing's Disease

Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline

Omayma ElShafie, Anjum Osman, Fatima Aamer, Ali Al-Mamari, N. J Y Woodhouse

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report five cases of Cushing's disease where the patients were given a therapeutic trial of cabergoline. Morning serum cortisol, adrenocorticotrophic hormone (ACTH), and sleeping cortisol concentrations were significantly raised. Magnetic resonance imaging (MRI) scans revealed pituitary microadenomas in 3 patients but were normal in the others. Ectopic ACTH production was excluded in the 2 patients with normal MRI scans. All were given a therapeutic trial of cabergoline (1 mg daily). Four patients responded with a prompt fall in serum cortisol levels and had a sustained clinical and biochemical remission for 378, 44, 28 and 14 days, respectively. One patient failed to respond. In conclusion, we suggest that all patients with Cushing's disease should undergo a therapeutic trial of cabergoline. Responders can then be prepared for surgery or, if needed, treated medically in the long term.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalSultan Qaboos University Medical Journal
Volume12
Issue number4
Publication statusPublished - Nov 2012

Fingerprint

Pituitary ACTH Hypersecretion
Dopamine Agonists
Hydrocortisone
Adrenocorticotropic Hormone
Therapeutics
Ectopic Hormones
Magnetic Resonance Imaging
Serum
cabergoline

Keywords

  • Adrenocorticotrophic hormone
  • Cabergoline
  • Case report
  • Cushing's disease
  • Dopamine receptors
  • Oman

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cushing's Disease : Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline. / ElShafie, Omayma; Osman, Anjum; Aamer, Fatima; Al-Mamari, Ali; Woodhouse, N. J Y.

In: Sultan Qaboos University Medical Journal, Vol. 12, No. 4, 11.2012, p. 493-497.

Research output: Contribution to journalArticle

@article{5980b198d74c4c40a71140da77d11ea8,
title = "Cushing's Disease: Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline",
abstract = "We report five cases of Cushing's disease where the patients were given a therapeutic trial of cabergoline. Morning serum cortisol, adrenocorticotrophic hormone (ACTH), and sleeping cortisol concentrations were significantly raised. Magnetic resonance imaging (MRI) scans revealed pituitary microadenomas in 3 patients but were normal in the others. Ectopic ACTH production was excluded in the 2 patients with normal MRI scans. All were given a therapeutic trial of cabergoline (1 mg daily). Four patients responded with a prompt fall in serum cortisol levels and had a sustained clinical and biochemical remission for 378, 44, 28 and 14 days, respectively. One patient failed to respond. In conclusion, we suggest that all patients with Cushing's disease should undergo a therapeutic trial of cabergoline. Responders can then be prepared for surgery or, if needed, treated medically in the long term.",
keywords = "Adrenocorticotrophic hormone, Cabergoline, Case report, Cushing's disease, Dopamine receptors, Oman",
author = "Omayma ElShafie and Anjum Osman and Fatima Aamer and Ali Al-Mamari and Woodhouse, {N. J Y}",
year = "2012",
month = "11",
language = "English",
volume = "12",
pages = "493--497",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "4",

}

TY - JOUR

T1 - Cushing's Disease

T2 - Sustained remission in five cases induced by medical therapy with the dopamine agonist cabergoline

AU - ElShafie, Omayma

AU - Osman, Anjum

AU - Aamer, Fatima

AU - Al-Mamari, Ali

AU - Woodhouse, N. J Y

PY - 2012/11

Y1 - 2012/11

N2 - We report five cases of Cushing's disease where the patients were given a therapeutic trial of cabergoline. Morning serum cortisol, adrenocorticotrophic hormone (ACTH), and sleeping cortisol concentrations were significantly raised. Magnetic resonance imaging (MRI) scans revealed pituitary microadenomas in 3 patients but were normal in the others. Ectopic ACTH production was excluded in the 2 patients with normal MRI scans. All were given a therapeutic trial of cabergoline (1 mg daily). Four patients responded with a prompt fall in serum cortisol levels and had a sustained clinical and biochemical remission for 378, 44, 28 and 14 days, respectively. One patient failed to respond. In conclusion, we suggest that all patients with Cushing's disease should undergo a therapeutic trial of cabergoline. Responders can then be prepared for surgery or, if needed, treated medically in the long term.

AB - We report five cases of Cushing's disease where the patients were given a therapeutic trial of cabergoline. Morning serum cortisol, adrenocorticotrophic hormone (ACTH), and sleeping cortisol concentrations were significantly raised. Magnetic resonance imaging (MRI) scans revealed pituitary microadenomas in 3 patients but were normal in the others. Ectopic ACTH production was excluded in the 2 patients with normal MRI scans. All were given a therapeutic trial of cabergoline (1 mg daily). Four patients responded with a prompt fall in serum cortisol levels and had a sustained clinical and biochemical remission for 378, 44, 28 and 14 days, respectively. One patient failed to respond. In conclusion, we suggest that all patients with Cushing's disease should undergo a therapeutic trial of cabergoline. Responders can then be prepared for surgery or, if needed, treated medically in the long term.

KW - Adrenocorticotrophic hormone

KW - Cabergoline

KW - Case report

KW - Cushing's disease

KW - Dopamine receptors

KW - Oman

UR - http://www.scopus.com/inward/record.url?scp=84870677495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870677495&partnerID=8YFLogxK

M3 - Article

VL - 12

SP - 493

EP - 497

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 4

ER -