CuS nanoparticles-enhanced luminol-O2 chemiluminescence reaction used for determination of paracetamol and vancomycin

Mortaza Iranifam*, Mahtab Toolooe Gardeh Rasht, Haider A.J. Al Lawati

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A new chemiluminescence (CL) method was proposed to measure two widely used drugs, including paracetamol (PCM) and vancomycin (VAN). The CL reaction used was the CuS nanoparticles (CuS NPs)-luminol-O2 system. In this system, CuS NPs played the role of catalyst and increased the CL intensity. CuS NPs were easily synthesized by quick-precipitation. CuS NPs were characterized by spectroscopic techniques, and the mean size of NPs was estimated to be about 9 nm. In the developed CL methods, PCM and VAN decreased the CL intensity. In the proposed method, the linear concentration ranges were 4.0 × 10−5–4.0 × 10−4 mol L-1 of PCM and 2.0 × 10−5–6.0 × 10−4 mol L−1 of VAN. The limit of detections were 2.9 × 10-5 mol L-1 and 8.9 × 10-6 mol L-1 for PCM and VAN, respectively. The relative standard deviations (RSD) of the CL method were 2.99 and 4.31 (n = 6) for the determination of 3.0 × 10−4 mol L−1 PCM and VAN, respectively. It was also shown that the CL methods can measure PCM and VAN concentrations in various real samples.

Original languageEnglish
Article number120038
JournalSpectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Publication statusPublished - Nov 15 2021
Externally publishedYes


  • Chemiluminescence
  • CuS nanoparticles
  • Luminol
  • Paracetamol
  • Vancomycin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Spectroscopy

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