TY - JOUR
T1 - CuS nanoparticles-enhanced luminol-O2 chemiluminescence reaction used for determination of paracetamol and vancomycin
AU - Iranifam, Mortaza
AU - Toolooe Gardeh Rasht, Mahtab
AU - Al Lawati, Haider A.J.
N1 - Funding Information:
The authors thank the University of Maragheh for all the support. Mortaza Iranifam appreciates the contributions and support of the Central laboratory of the University of Maragheh. Moreover, Mortaza Iranifam would like to thank Ms. Iman Al- Lawati from Sultan Qaboos University, Sultanate of Oman for their help in taking TEM images.
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/11/15
Y1 - 2021/11/15
N2 - A new chemiluminescence (CL) method was proposed to measure two widely used drugs, including paracetamol (PCM) and vancomycin (VAN). The CL reaction used was the CuS nanoparticles (CuS NPs)-luminol-O2 system. In this system, CuS NPs played the role of catalyst and increased the CL intensity. CuS NPs were easily synthesized by quick-precipitation. CuS NPs were characterized by spectroscopic techniques, and the mean size of NPs was estimated to be about 9 nm. In the developed CL methods, PCM and VAN decreased the CL intensity. In the proposed method, the linear concentration ranges were 4.0 × 10−5–4.0 × 10−4 mol L-1 of PCM and 2.0 × 10−5–6.0 × 10−4 mol L−1 of VAN. The limit of detections were 2.9 × 10-5 mol L-1 and 8.9 × 10-6 mol L-1 for PCM and VAN, respectively. The relative standard deviations (RSD) of the CL method were 2.99 and 4.31 (n = 6) for the determination of 3.0 × 10−4 mol L−1 PCM and VAN, respectively. It was also shown that the CL methods can measure PCM and VAN concentrations in various real samples.
AB - A new chemiluminescence (CL) method was proposed to measure two widely used drugs, including paracetamol (PCM) and vancomycin (VAN). The CL reaction used was the CuS nanoparticles (CuS NPs)-luminol-O2 system. In this system, CuS NPs played the role of catalyst and increased the CL intensity. CuS NPs were easily synthesized by quick-precipitation. CuS NPs were characterized by spectroscopic techniques, and the mean size of NPs was estimated to be about 9 nm. In the developed CL methods, PCM and VAN decreased the CL intensity. In the proposed method, the linear concentration ranges were 4.0 × 10−5–4.0 × 10−4 mol L-1 of PCM and 2.0 × 10−5–6.0 × 10−4 mol L−1 of VAN. The limit of detections were 2.9 × 10-5 mol L-1 and 8.9 × 10-6 mol L-1 for PCM and VAN, respectively. The relative standard deviations (RSD) of the CL method were 2.99 and 4.31 (n = 6) for the determination of 3.0 × 10−4 mol L−1 PCM and VAN, respectively. It was also shown that the CL methods can measure PCM and VAN concentrations in various real samples.
KW - Chemiluminescence
KW - CuS nanoparticles
KW - Luminol
KW - Paracetamol
KW - Vancomycin
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U2 - 10.1016/j.saa.2021.120038
DO - 10.1016/j.saa.2021.120038
M3 - Article
C2 - 34118521
AN - SCOPUS:85108074087
SN - 1386-1425
VL - 261
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
M1 - 120038
ER -