Current concepts in the pathology and epigenetics of endometrial carcinoma

Mohammad Arafa, Joan Somja, Pierre Dehan, Frédéric Kridelka, Frédéric Goffin, Jacques Boniver, Philippe Delvenne

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)


In the Western world, endometrial carcinoma is the most common malignant tumour of the female genital tract and is the fourth most common cancer in women. Two different clinicopathological subtypes are recognised: the oestrogen-related (type I, endometrioid) and the non-oestrogen related (type II, non-endometrioid). This article reviews the epidemiology, risk factors, genetic alterations during endometrial carcinogenesis, features of tumours and precursors and early detection of the disease. Insights into the epigenetic alterations, with emphasis on DNA methylation during endometrial carcinogenesis, and their diagnostic value are also provided.

Original languageEnglish
Pages (from-to)613-7
Number of pages5
Issue number7
Publication statusPublished - Dec 2010


  • Carcinoma, Endometrioid/genetics
  • Cell Transformation, Neoplastic/genetics
  • DNA Methylation
  • Endometrial Neoplasms/epidemiology
  • Epigenesis, Genetic
  • Epigenomics/trends
  • Female
  • Humans
  • Risk Factors

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