Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease

Badreldin H. Ali, Suhail Al-Salam, Yousuf Al Suleimani, Jamila Al Kalbani, Shadia Al Bahlani, Mohammed Ashique, Priyadarsini Manoj, Buthaina Al Dhahli, Nadia Al Abri, Heba T. Naser, Javed Yasin, Abderrahim Nemmar, Mohammed Al Za'abi, Christina Hartmann, Nicole Schupp

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue. Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities. Curcumin markedly reduced renal morphological damage and histopathological markers of inflammation, fibrosis and apoptosis. Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin. It restored plasma sclerostin concentrations and lowered oxidative stress in renal homogenates. In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level. In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.

Original languageEnglish
JournalBasic and Clinical Pharmacology and Toxicology
DOIs
Publication statusAccepted/In press - 2017

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Curcumin
Oxidative stress
Chronic Renal Insufficiency
Adenine
Oxidative Stress
Kidney
Rats
Inflammation
Transcription Factors
Up-Regulation
Apoptosis
Lipocalins
Plasmas
Cystatin C
Hexosaminidases
Curcuma
Gelatinases
Glutathione Reductase
Poisons
Adiponectin

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease. / Ali, Badreldin H.; Al-Salam, Suhail; Al Suleimani, Yousuf; Al Kalbani, Jamila; Al Bahlani, Shadia; Ashique, Mohammed; Manoj, Priyadarsini; Al Dhahli, Buthaina; Al Abri, Nadia; Naser, Heba T.; Yasin, Javed; Nemmar, Abderrahim; Al Za'abi, Mohammed; Hartmann, Christina; Schupp, Nicole.

In: Basic and Clinical Pharmacology and Toxicology, 2017.

Research output: Contribution to journalArticle

Ali, Badreldin H. ; Al-Salam, Suhail ; Al Suleimani, Yousuf ; Al Kalbani, Jamila ; Al Bahlani, Shadia ; Ashique, Mohammed ; Manoj, Priyadarsini ; Al Dhahli, Buthaina ; Al Abri, Nadia ; Naser, Heba T. ; Yasin, Javed ; Nemmar, Abderrahim ; Al Za'abi, Mohammed ; Hartmann, Christina ; Schupp, Nicole. / Curcumin Ameliorates Kidney Function and Oxidative Stress in Experimental Chronic Kidney Disease. In: Basic and Clinical Pharmacology and Toxicology. 2017.
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abstract = "Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue. Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities. Curcumin markedly reduced renal morphological damage and histopathological markers of inflammation, fibrosis and apoptosis. Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin. It restored plasma sclerostin concentrations and lowered oxidative stress in renal homogenates. In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level. In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.",
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AU - Ali, Badreldin H.

AU - Al-Salam, Suhail

AU - Al Suleimani, Yousuf

AU - Al Kalbani, Jamila

AU - Al Bahlani, Shadia

AU - Ashique, Mohammed

AU - Manoj, Priyadarsini

AU - Al Dhahli, Buthaina

AU - Al Abri, Nadia

AU - Naser, Heba T.

AU - Yasin, Javed

AU - Nemmar, Abderrahim

AU - Al Za'abi, Mohammed

AU - Hartmann, Christina

AU - Schupp, Nicole

PY - 2017

Y1 - 2017

N2 - Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue. Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities. Curcumin markedly reduced renal morphological damage and histopathological markers of inflammation, fibrosis and apoptosis. Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin. It restored plasma sclerostin concentrations and lowered oxidative stress in renal homogenates. In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level. In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.

AB - Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory and anti-apoptotic activities on kidney structure and function in rats with adenine-induced CKD. Rats were treated for 5 weeks with adenine to induce CKD-like renal damage and combined with three doses of curcumin. Markers of kidney function and oxidative stress were quantified in plasma, urine, renal homogenates and on kidney tissue. Curcumin was found to significantly abate adenine-induced toxic effects such as reduced creatinine clearance, elevated neutrophil gelatinase-associated lipocalin levels and raised urinary N-acetyl-β-D-glucosaminidase activities. Curcumin markedly reduced renal morphological damage and histopathological markers of inflammation, fibrosis and apoptosis. Curcumin further reduced adenine-induced hypertension, urinary albumin, the inflammatory cytokines IL-1β, IL-6 and TNF-α, cystatin C and adiponectin. It restored plasma sclerostin concentrations and lowered oxidative stress in renal homogenates. In animals treated with the two higher curcumin concentrations, alone or in combination with adenine, an increased expression of the antioxidative transcription factor Nrf2 was found as well as up-regulation of the activity of its direct target glutathione reductase, and of an indirect target, the glutathione level. In conclusion, curcumin exhibits salutary effects against adenine-induced CKD in rats by reducing inflammation and oxidative stress via up-regulation of the transcription factor Nrf2.

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