Criteria for diagnosis of familial hypercholesterolemia: A comprehensive analysis of the different guidelines, appraising their suitability in the Omani Arab population

Khalid Al-Rasadi, Khalid Al-Waili, Hilal Ali Al-Sabti, Ali Al-Hinai, Khamis Al-Hashmi, Ibrahim Al-Zakwani, Yajnavalka Banerjee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as premature myocardial infarction and early death from coronary heart disease, especially in patients with severe forms of the disease if left unattended. Therefore, there is an ardent need for the early diagnosis followed by aggressive therapeutic intervention and lifestyle modification. Three groups have developed clinical diagnostic tools for Familial hypercholesterolemia: the US MedPed Program, the Simon Broome Register Group in the United Kingdom, and the Dutch Lipid Clinic Network. In this article, the individual criteria are reviewed with particular emphasis on their advantage(s) and disadvantage(s), and in turn assess their suitability in diagnosing Familial hypercholesterolemia in the Omani Arab population. A brief insight into the process of "Cascade Screening" is also provided, this is a procedure that we are in the process of establishing in Oman.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalOman Medical Journal
Volume29
Issue number2
DOIs
Publication statusPublished - 2014

Fingerprint

Hyperlipoproteinemia Type II
Guidelines
Oman
Population
Coronary Disease
Life Style
Early Diagnosis
Myocardial Infarction
Lipids
Therapeutics

Keywords

  • Cascade-screening
  • Dutch criteria
  • Familial hypercholesterolemia
  • Omani Arab population
  • Simon-broome criteria
  • US-medped criteria

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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AU - Al-Rasadi, Khalid

AU - Al-Waili, Khalid

AU - Al-Sabti, Hilal Ali

AU - Al-Hinai, Ali

AU - Al-Hashmi, Khamis

AU - Al-Zakwani, Ibrahim

AU - Banerjee, Yajnavalka

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AB - Subjects with Familial hypercholesterolemia are at increased risk for cardiac events such as premature myocardial infarction and early death from coronary heart disease, especially in patients with severe forms of the disease if left unattended. Therefore, there is an ardent need for the early diagnosis followed by aggressive therapeutic intervention and lifestyle modification. Three groups have developed clinical diagnostic tools for Familial hypercholesterolemia: the US MedPed Program, the Simon Broome Register Group in the United Kingdom, and the Dutch Lipid Clinic Network. In this article, the individual criteria are reviewed with particular emphasis on their advantage(s) and disadvantage(s), and in turn assess their suitability in diagnosing Familial hypercholesterolemia in the Omani Arab population. A brief insight into the process of "Cascade Screening" is also provided, this is a procedure that we are in the process of establishing in Oman.

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