Abstract
Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p
| Original language | English |
|---|---|
| Pages (from-to) | 365-368 |
| Number of pages | 4 |
| Journal | Hemoglobin |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Oct 1 2014 |
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Keywords
- Cystatin C
- Glomerular filtration rate
- Thalassemia
ASJC Scopus subject areas
- Hematology
- Genetics(clinical)
- Clinical Biochemistry
- Biochemistry, medical
- Medicine(all)
Cite this
Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major. / Al-Khabori, Murtadha; Bhandari, Sunil; Al-Rasadi, Khalid; Mevada, Surekha; Al-Dhuhli, Hamoud; Al-Kemyani, Nasser; Daar, Shahina.
In: Hemoglobin, Vol. 38, No. 5, 01.10.2014, p. 365-368.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major
AU - Al-Khabori, Murtadha
AU - Bhandari, Sunil
AU - Al-Rasadi, Khalid
AU - Mevada, Surekha
AU - Al-Dhuhli, Hamoud
AU - Al-Kemyani, Nasser
AU - Daar, Shahina
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p
AB - Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p
KW - Cystatin C
KW - Glomerular filtration rate
KW - Thalassemia
UR - http://www.scopus.com/inward/record.url?scp=84907501714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907501714&partnerID=8YFLogxK
U2 - 10.3109/03630269.2014.944314
DO - 10.3109/03630269.2014.944314
M3 - Article
VL - 38
SP - 365
EP - 368
JO - Hemoglobin
JF - Hemoglobin
SN - 0363-0269
IS - 5
ER -