Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major

Murtadha Al-Khabori, Sunil Bhandari, Khalid Al-Rasadi, Surekha Mevada, Hamoud Al-Dhuhli, Nasser Al-Kemyani, Shahina Daar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p

Original languageEnglish
Pages (from-to)365-368
Number of pages4
JournalHemoglobin
Volume38
Issue number5
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Cystatin C
Iron Overload
beta-Thalassemia
Ferritins
Glomerular Filtration Rate
Iron
Deferoxamine
Medical problems
Serum
Linear regression
Oman
Linear Models
Diabetes Mellitus
Cross-Sectional Studies
Kidney
deferiprone

Keywords

  • Cystatin C
  • Glomerular filtration rate
  • Thalassemia

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

Cite this

Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major. / Al-Khabori, Murtadha; Bhandari, Sunil; Al-Rasadi, Khalid; Mevada, Surekha; Al-Dhuhli, Hamoud; Al-Kemyani, Nasser; Daar, Shahina.

In: Hemoglobin, Vol. 38, No. 5, 01.10.2014, p. 365-368.

Research output: Contribution to journalArticle

@article{d06e0d5fb63448f59bb8ecf678bfbb81,
title = "Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major",
abstract = "Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p",
keywords = "Cystatin C, Glomerular filtration rate, Thalassemia",
author = "Murtadha Al-Khabori and Sunil Bhandari and Khalid Al-Rasadi and Surekha Mevada and Hamoud Al-Dhuhli and Nasser Al-Kemyani and Shahina Daar",
year = "2014",
month = "10",
day = "1",
doi = "10.3109/03630269.2014.944314",
language = "English",
volume = "38",
pages = "365--368",
journal = "Hemoglobin",
issn = "0363-0269",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Correlation of iron overload and glomerular filtration rate estimated by cystatin C in patients with β-thalassemia major

AU - Al-Khabori, Murtadha

AU - Bhandari, Sunil

AU - Al-Rasadi, Khalid

AU - Mevada, Surekha

AU - Al-Dhuhli, Hamoud

AU - Al-Kemyani, Nasser

AU - Daar, Shahina

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p

AB - Historically, renal involvement has not been a commonly recognized complication in patients with β-thalassemia major (β-TM). Herein, we studied the impact of iron overload on glomerular filtration rate (GFR) estimated by cystatin C based GFR (Cyst C eGFR). We enrolled 149 patients with β-TM in a cross sectional study in a single center in Oman. We investigated the correlation between measurement of serum ferritin and Cyst C eGFR. We used univariable linear regression to study the impact of serum ferritin on Cyst C eGFR and backwards stepwise regression to adjust for potential confounders. We included 78 males and 71 females with a mean age of 17.3±9 years (range 2.5-38.5). Seventeen patients had diabetes mellitus. Patients were taking deferiprone (DFP) and deferoxamine (DFO) (26 patients), DFP (58 patients), deferasirox (DFX) (62 patients) and one patient was taking only DFO. There was a very weak negative linear relationship between serum ferritin and Cyst C eGFR (correlation coefficient -0.25). In the univariable analyses, serum ferritin (p=0.004), diabetes status (p

KW - Cystatin C

KW - Glomerular filtration rate

KW - Thalassemia

UR - http://www.scopus.com/inward/record.url?scp=84907501714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907501714&partnerID=8YFLogxK

U2 - 10.3109/03630269.2014.944314

DO - 10.3109/03630269.2014.944314

M3 - Article

C2 - 25074643

AN - SCOPUS:84907501714

VL - 38

SP - 365

EP - 368

JO - Hemoglobin

JF - Hemoglobin

SN - 0363-0269

IS - 5

ER -