Constant light influences the circadian oscillations of circulatory lipid peroxidation, antioxidants and some biochemical variables in rats

S. Subash, P. Subramanian, R. Sivaperumal, T. Manivasagam, M. Mohamed Essa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Temporal oscillations of circulatory thiobarbituric acid reactive substances (TBARS), antioxidants such as reduced glutathione (GSH), superoxide dismutase (SOD), and catalase and glucose, cholesterol, total protein and aspartate transaminase (AST) were studied under LD (12:12 h) and constant light (LL) (500 lux) conditions after exposing the animal for 21 days. Advances in the acrophase of GSH, SOD, catalase, glucose, total protein and (AST) rhythms and delays in TBARS and cholesterol were found; amplitude and mesor values of these rhythms were found to be altered during constant light treatment. The above said circadian alterations during LL exposure may be due to (1) formation of photooxidants and stress mediated lipid peroxidation, suppression of melatonin (2) modulation of neuroendocrine and neurotransmitters rhythm (3) suppression of sleep-wake cycle (4) feeding and locomotion rhythm. The exact mechanism still remains to be explored and further research needed.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalBiological Rhythm Research
Volume37
Issue number6
DOIs
Publication statusPublished - Dec 1 2006

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Thiobarbituric Acid Reactive Substances
Aspartate Aminotransferases
thiobarbituric acid-reactive substances
aspartate transaminase
Catalase
antioxidant
Lipid Peroxidation
Superoxide Dismutase
oscillation
catalase
superoxide dismutase
glucose
lipid peroxidation
Antioxidants
lipid
Cholesterol
cholesterol
antioxidants
Light
Glucose

Keywords

  • Antioxidants
  • AST
  • Cholesterol
  • Circadian
  • Continuous light
  • Glucose
  • TBARS
  • Total protein

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Physiology

Cite this

Constant light influences the circadian oscillations of circulatory lipid peroxidation, antioxidants and some biochemical variables in rats. / Subash, S.; Subramanian, P.; Sivaperumal, R.; Manivasagam, T.; Essa, M. Mohamed.

In: Biological Rhythm Research, Vol. 37, No. 6, 01.12.2006, p. 471-477.

Research output: Contribution to journalArticle

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