Consanguinity, endogamy and inborn errors of metabolism in Oman

A cross-sectional study

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The Sultanate of Oman, like many other Arab countries, has relatively high rates of consanguinity. Reports suggest that the incidence of inborn errors of metabolism (IEM) is also high in Oman. This retrospective cross-sectional study was designed to evaluate the number of patients with IEM being followed at the only two tertiary centers in Oman treating such patients, and to calculate the consanguinity rates among these families. The electronic medical records of all patients were reviewed for demographic and clinical characteristics. A total of 285 patients with IEM were being followed at the 2 centers involved; 162 (56.8%) were male and 123 (43.2%) were female. The history of consanguinity was documented or available for 241 patients: 229 patients (95%) were born to consanguineous parents related as second cousins or closer. First-cousin marriages were reported in 191 families (79.3%), while 31 patients (12.9%) were born to second cousins. The parents of 5 patients (2%) were related as double first cousins, and 2 patients (1%) were born to first cousins once removed. The average coefficient of inbreeding (F) in our study was 0.081. Seventeen patients (6%) had associated comorbid conditions other than IEM. Our study highlights the clinical burden of IEM in Oman and emphasizes the high consanguinity rates among the parents of affected patients.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalHuman Heredity
Volume77
Issue number1-4
DOIs
Publication statusPublished - 2014

Fingerprint

Oman
Consanguinity
Inborn Errors Metabolism
Cross-Sectional Studies
Parents
Middle East
Inbreeding
Electronic Health Records
Marriage

Keywords

  • Coefficient of inbreeding
  • Consanguinity
  • Endogamy
  • Inborn errors of metabolism
  • Oman

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Medicine(all)

Cite this

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title = "Consanguinity, endogamy and inborn errors of metabolism in Oman: A cross-sectional study",
abstract = "The Sultanate of Oman, like many other Arab countries, has relatively high rates of consanguinity. Reports suggest that the incidence of inborn errors of metabolism (IEM) is also high in Oman. This retrospective cross-sectional study was designed to evaluate the number of patients with IEM being followed at the only two tertiary centers in Oman treating such patients, and to calculate the consanguinity rates among these families. The electronic medical records of all patients were reviewed for demographic and clinical characteristics. A total of 285 patients with IEM were being followed at the 2 centers involved; 162 (56.8{\%}) were male and 123 (43.2{\%}) were female. The history of consanguinity was documented or available for 241 patients: 229 patients (95{\%}) were born to consanguineous parents related as second cousins or closer. First-cousin marriages were reported in 191 families (79.3{\%}), while 31 patients (12.9{\%}) were born to second cousins. The parents of 5 patients (2{\%}) were related as double first cousins, and 2 patients (1{\%}) were born to first cousins once removed. The average coefficient of inbreeding (F) in our study was 0.081. Seventeen patients (6{\%}) had associated comorbid conditions other than IEM. Our study highlights the clinical burden of IEM in Oman and emphasizes the high consanguinity rates among the parents of affected patients.",
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