Complexation and molecular modeling studies of europium(III)-gallic acid-amino acid complexes

Mohamed Taha, Imran Khan, João A.P. Coutinho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

With many metal-based drugs extensively used today in the treatment of cancer, attention has focused on the development of new coordination compounds with antitumor activity with europium(III) complexes recently introduced as novel anticancer drugs. The aim of this work is to design new Eu(III) complexes with gallic acid, an antioxida'nt phenolic compound. Gallic acid was chosen because it shows anticancer activity without harming health cells. As antioxidant, it helps to protect human cells against oxidative damage that implicated in DNA damage, cancer, and accelerated cell aging. In this work, the formation of binary and ternary complexes of Eu(III) with gallic acid, primary ligand, and amino acids alanine, leucine, isoleucine, and tryptophan was studied by glass electrode potentiometry in aqueous solution containing 0.1 M NaNO3 at (298.2 ± 0.1) K. Their overall stability constants were evaluated and the concentration distributions of the complex species in solution were calculated. The protonation constants of gallic acid and amino acids were also determined at our experimental conditions and compared with those predicted by using conductor-like screening model for realistic solvation (COSMO-RS) model. The geometries of Eu(III)-gallic acid complexes were characterized by the density functional theory (DFT). The spectroscopic UV-visible and photoluminescence measurements are carried out to confirm the formation of Eu(III)-gallic acid complexes in aqueous solutions.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalJournal of Inorganic Biochemistry
Volume157
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Europium
Gallic Acid
Molecular modeling
Complexation
Amino Acids
tryptophan-leucine
Potentiometry
Isoleucine
Cell Aging
Protonation
Solvation
Leucine
Tryptophan
Alanine
Pharmaceutical Preparations
DNA Damage
Density functional theory
Glass
Neoplasms
Photoluminescence

Keywords

  • Amino acids
  • COSMO-RS
  • DFT
  • Eu(III) complexes
  • Gallic acid
  • Stability constants

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

Cite this

Complexation and molecular modeling studies of europium(III)-gallic acid-amino acid complexes. / Taha, Mohamed; Khan, Imran; Coutinho, João A.P.

In: Journal of Inorganic Biochemistry, Vol. 157, 01.04.2016, p. 25-33.

Research output: Contribution to journalArticle

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