Comparison of estrogen receptors, progesterone receptors and HER-2/neu expression between primary and metastatic breast carcinoma

Muhammad Azam, Asim Qureshi, Samina Mansoor

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine whether receptor status and HER-2/neu status remains same in primary and metastatic breast carcinoma to corresponding lymph nodes of individual patients. Methods: Estrogen receptors, progesterone receptors and HER-2/neu immunohistochemical stains were performed on primary and metastatic breast carcinoma to axillary lymph nodes in 100 patients. Data was collected on a Performa and age, tumour size, type, grade and expression of ER, PR and HER-2/neu on primary and metastatic tumours were recorded. Results: Hormone receptor status was compared between primary and metastatic tumours. Estrogen receptor positivity was observed in 28% primary tumours which were reduced to 25% in metastatic carcinoma. Progesterone receptors were positive in 28% primary tumours as compared to 22% in metastatic tumours. Her-2/neu protein over expression was noted in 44% primary and 45% metastatic breast tumours respectively. In case to case comparison ER, PR and HER-2/neu showed 91%, 88% and 95% concordance in primary and metastatic tumours respectively. Conclusion: ER, PR and HER-2/neu biomarkers showed significant concordance between primary and metastatic breast carcinoma.

Original languageEnglish
Pages (from-to)736-740
Number of pages5
JournalJournal of the Pakistan Medical Association
Volume59
Issue number11
Publication statusPublished - Nov 2009

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Progesterone Receptors
Estrogen Receptors
Breast Neoplasms
Neoplasms
Lymph Nodes
Coloring Agents
Biomarkers
Hormones
Carcinoma
Proteins

ASJC Scopus subject areas

  • Medicine(all)

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Comparison of estrogen receptors, progesterone receptors and HER-2/neu expression between primary and metastatic breast carcinoma. / Azam, Muhammad; Qureshi, Asim; Mansoor, Samina.

In: Journal of the Pakistan Medical Association, Vol. 59, No. 11, 11.2009, p. 736-740.

Research output: Contribution to journalArticle

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abstract = "Objective: To determine whether receptor status and HER-2/neu status remains same in primary and metastatic breast carcinoma to corresponding lymph nodes of individual patients. Methods: Estrogen receptors, progesterone receptors and HER-2/neu immunohistochemical stains were performed on primary and metastatic breast carcinoma to axillary lymph nodes in 100 patients. Data was collected on a Performa and age, tumour size, type, grade and expression of ER, PR and HER-2/neu on primary and metastatic tumours were recorded. Results: Hormone receptor status was compared between primary and metastatic tumours. Estrogen receptor positivity was observed in 28{\%} primary tumours which were reduced to 25{\%} in metastatic carcinoma. Progesterone receptors were positive in 28{\%} primary tumours as compared to 22{\%} in metastatic tumours. Her-2/neu protein over expression was noted in 44{\%} primary and 45{\%} metastatic breast tumours respectively. In case to case comparison ER, PR and HER-2/neu showed 91{\%}, 88{\%} and 95{\%} concordance in primary and metastatic tumours respectively. Conclusion: ER, PR and HER-2/neu biomarkers showed significant concordance between primary and metastatic breast carcinoma.",
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N2 - Objective: To determine whether receptor status and HER-2/neu status remains same in primary and metastatic breast carcinoma to corresponding lymph nodes of individual patients. Methods: Estrogen receptors, progesterone receptors and HER-2/neu immunohistochemical stains were performed on primary and metastatic breast carcinoma to axillary lymph nodes in 100 patients. Data was collected on a Performa and age, tumour size, type, grade and expression of ER, PR and HER-2/neu on primary and metastatic tumours were recorded. Results: Hormone receptor status was compared between primary and metastatic tumours. Estrogen receptor positivity was observed in 28% primary tumours which were reduced to 25% in metastatic carcinoma. Progesterone receptors were positive in 28% primary tumours as compared to 22% in metastatic tumours. Her-2/neu protein over expression was noted in 44% primary and 45% metastatic breast tumours respectively. In case to case comparison ER, PR and HER-2/neu showed 91%, 88% and 95% concordance in primary and metastatic tumours respectively. Conclusion: ER, PR and HER-2/neu biomarkers showed significant concordance between primary and metastatic breast carcinoma.

AB - Objective: To determine whether receptor status and HER-2/neu status remains same in primary and metastatic breast carcinoma to corresponding lymph nodes of individual patients. Methods: Estrogen receptors, progesterone receptors and HER-2/neu immunohistochemical stains were performed on primary and metastatic breast carcinoma to axillary lymph nodes in 100 patients. Data was collected on a Performa and age, tumour size, type, grade and expression of ER, PR and HER-2/neu on primary and metastatic tumours were recorded. Results: Hormone receptor status was compared between primary and metastatic tumours. Estrogen receptor positivity was observed in 28% primary tumours which were reduced to 25% in metastatic carcinoma. Progesterone receptors were positive in 28% primary tumours as compared to 22% in metastatic tumours. Her-2/neu protein over expression was noted in 44% primary and 45% metastatic breast tumours respectively. In case to case comparison ER, PR and HER-2/neu showed 91%, 88% and 95% concordance in primary and metastatic tumours respectively. Conclusion: ER, PR and HER-2/neu biomarkers showed significant concordance between primary and metastatic breast carcinoma.

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