Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats

B. H. Ali, Z. Cheng, G. El Hadrami, A. K. Bashir, Q. A. Mckellar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P <0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume19
Issue number3
Publication statusPublished - 1996

Fingerprint

acetaminophen
Camelus
camels
Acetaminophen
Goats
pharmacokinetics
deserts
sulfates
Pharmacokinetics
goats
metabolites
Glucuronides
intravenous injection
Intravenous Administration
Sulfates
Area Under Curve
intramuscular injection
Biological Availability
half life
Half-Life

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats. / Ali, B. H.; Cheng, Z.; El Hadrami, G.; Bashir, A. K.; Mckellar, Q. A.

In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 19, No. 3, 1996, p. 238-244.

Research output: Contribution to journalArticle

@article{d6a6c18824ea4babacb7db1b49aa90a5,
title = "Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats",
abstract = "Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P <0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89{\%} of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17{\%} in goats and 105 ± 26{\%} in camels.",
author = "Ali, {B. H.} and Z. Cheng and {El Hadrami}, G. and Bashir, {A. K.} and Mckellar, {Q. A.}",
year = "1996",
language = "English",
volume = "19",
pages = "238--244",
journal = "Journal of Veterinary Pharmacology and Therapeutics",
issn = "0140-7783",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Comparative pharmacokinetics of paracetamol (acetaminophen) and its sulphate and glucuronide metabolites in desert camels and goats

AU - Ali, B. H.

AU - Cheng, Z.

AU - El Hadrami, G.

AU - Bashir, A. K.

AU - Mckellar, Q. A.

PY - 1996

Y1 - 1996

N2 - Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P <0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.

AB - Paracetamol was administered at dosages of 5 mg/kg to camels and 10 mg/kg to goats by the intravenous and intramuscular routes, Parent paracetamol had a significantly slower clearance (21.9 ± 1.4 mL/min·kg vs, 52.8 ± 7.3 mL/min·kg) (P <0.01) in camels than in goats. In camels the predominant metabolite in plasma was the sulphate, although the ratios of glucuronide:paracetamol and sulphate:paracetamol were similar (5.20 ± 0.50 vs. 6.59 ± 0.51) following intravenous administration. In goats the glucuronide metabolite was the predominant moiety in plasma, and the area under the curve (AUC) of the sulphate was only 3.89% of that of the glucuronide conjugate, The apparent AUC for paracetamol in the camel following intramuscular administration was larger than that following intravenous administration, however, when the bioavailability (F) was determined, with correction for altered half-life, within the animal and between study phases it was 71 ± 17% in goats and 105 ± 26% in camels.

UR - http://www.scopus.com/inward/record.url?scp=0029898703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029898703&partnerID=8YFLogxK

M3 - Article

VL - 19

SP - 238

EP - 244

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 3

ER -