Comparative pharmacokinetics of metronidazole in camels, sheep and goats

B. H. Ali, B. G. Charles, M. Al-Yousif, A. K. Bashir

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1 Citation (Scopus)

Abstract

The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalActa Veterinaria Brno
Volume72
Issue number1
Publication statusPublished - 2003

Keywords

  • Antibacterials
  • Antiprotozoals
  • Kinetics
  • Metronidazole
  • Ruminants

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Ali, B. H., Charles, B. G., Al-Yousif, M., & Bashir, A. K. (2003). Comparative pharmacokinetics of metronidazole in camels, sheep and goats. Acta Veterinaria Brno, 72(1), 49-53.