Comparative pharmacokinetics of metronidazole in camels, sheep and goats

B. H. Ali; B. G. Charles; M. Al-Yousif; A. K. Bashir

doi:10.2754/avb200372010049

Comparative pharmacokinetics of metronidazole in camels, sheep and goats

B. H. Ali^*, B. G. Charles, M. Al-Yousif, A. K. Bashir

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg^-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t_1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, C_max (mg·ml^-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach C_max, t_max (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg^-1 in camels and 10 mg·kg^-1 in sheep and goats, every 12 h.

Original language	English
Pages (from-to)	49-53
Number of pages	5
Journal	Acta Veterinaria Brno
Volume	72
Issue number	1
DOIs	https://doi.org/10.2754/avb200372010049
Publication status	Published - 2003
Externally published	Yes

Keywords

Antibacterials
Antiprotozoals
Kinetics
Metronidazole
Ruminants

ASJC Scopus subject areas

General Veterinary

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title = "Comparative pharmacokinetics of metronidazole in camels, sheep and goats",

abstract = "The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.",

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author = "Ali, {B. H.} and Charles, {B. G.} and M. Al-Yousif and Bashir, {A. K.}",

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AU - Ali, B. H.

AU - Charles, B. G.

AU - Al-Yousif, M.

AU - Bashir, A. K.

PY - 2003

Y1 - 2003

N2 - The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.

AB - The pharmacokinetics of metronidazole was determined after a single intramuscular (i.m.) dose of 30 mg·kg-1-body weight in five camels, sheep and goats. Marked differences were found between the three species in some of the kinetic parameters. For example, the elimination half-lives (t1/2; h) in camels, sheep and goats were 10.0, 6.21 and 5.87, respectively. The drug maximum concentrations in plasma, Cmax (mg·ml-1), were 28.3, 54.6 and 54.4 in camels, sheep and goats. respectively. The time to reach Cmax, tmax (h), were 5, 4 and 2 in camels, sheep and goats, respectively. The mean residence times (MRT; h) in camels, sheep and goats were 16.7, 10.8 and 8.64, respectively. In the light of the present kinetic data and known microbial sensitivities of metronidazole, we recommend an i.m. dose of 15 mg·kg-1 in camels and 10 mg·kg-1 in sheep and goats, every 12 h.

KW - Antibacterials

KW - Antiprotozoals

KW - Kinetics

KW - Metronidazole

KW - Ruminants

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Comparative pharmacokinetics of metronidazole in camels, sheep and goats

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Keywords

ASJC Scopus subject areas

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