Comparative in-vitro activity of trovafloxacin and other related drugs against isolates of streptococcus oralis

Research output: Contribution to journalArticle

Abstract

Objective: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various β-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis. Methods: Minimal inhibitory concentration was performed using the agar dilution technique and microtiter method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates. Results: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S. oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100% kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours. Conclusion: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.

Original languageEnglish
Pages (from-to)238-243
Number of pages6
JournalSaudi Medical Journal
Volume22
Issue number3
Publication statusPublished - Mar 2001

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Streptococcus oralis
Pharmaceutical Preparations
Anti-Bacterial Agents
Ciprofloxacin
Teicoplanin
Indicator Dilution Techniques
Lactams
Clindamycin
Quinolones
Erythromycin
Vancomycin
Agar
trovafloxacin
In Vitro Techniques

Keywords

  • Ciprofloxacin
  • Clindamycin
  • Erythromycin, β-lactam
  • S. oralis
  • Teicoplanin
  • Trovafloxacin
  • Vancomycin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Comparative in-vitro activity of trovafloxacin and other related drugs against isolates of streptococcus oralis",
abstract = "Objective: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various β-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis. Methods: Minimal inhibitory concentration was performed using the agar dilution technique and microtiter method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates. Results: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S. oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100{\%} kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours. Conclusion: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.",
keywords = "Ciprofloxacin, Clindamycin, Erythromycin, β-lactam, S. oralis, Teicoplanin, Trovafloxacin, Vancomycin",
author = "Rafay, {Akbar M.}",
year = "2001",
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language = "English",
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T1 - Comparative in-vitro activity of trovafloxacin and other related drugs against isolates of streptococcus oralis

AU - Rafay, Akbar M.

PY - 2001/3

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N2 - Objective: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various β-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis. Methods: Minimal inhibitory concentration was performed using the agar dilution technique and microtiter method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates. Results: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S. oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100% kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours. Conclusion: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.

AB - Objective: The in-vitro activity of trovafloxacin a new quinolone was compared with that of ciprofloxacin, erythromycin, various β-lactam and other appropriate antibiotics such as vancomycin, teicoplanin and clindamycin against 60 isolates of S. oralis. Methods: Minimal inhibitory concentration was performed using the agar dilution technique and microtiter method. In addition minimal bactericidal concentration and time-kill studies were carried out to estimate the bactericidal activity of trovafloxacin against S. oralis isolates. Results: Trovafloxacin showed a four-fold increase in activity over ciprofloxacin, with a narrow minimal inhibitory concentration range, MIC50 and mode values of 0.25 mg/l. Although the minimal inhibitory concentrations of trovafloxacin for S. oralis were relatively high compared to all the antibiotics tested. The in-vitro bactericidal activity of Trovafloxacin was greater than all other antibiotics against S. oralis. Five out of 10 isolates showed there was a 100% kill within 6 hours of contact; in all other cases, the kill time was between 6 and 24 hours. Conclusion: Overall, trovafloxacin showed superior minimal inhibitory concentration, bactericidal concentration and kill time when compared with different antibiotics.

KW - Ciprofloxacin

KW - Clindamycin

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KW - S. oralis

KW - Teicoplanin

KW - Trovafloxacin

KW - Vancomycin

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