Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India

Thomas Kurien, S. P. Thyagarajan, L. Jeyaseelan, A. Peedicayil, P. Rajendran, S. Sivaram, S. G. Hansdak, G. Renu, P. Krishnamurthy, K. Sudhakar, K. Varghese, A. G. Joyee, D. Hari, Lakshmi Bai, Vijaya Srinivasan, J. C. Varghese, N. Sethuraman Meenakshi, S. Hira, H. Gharpure, Soshamma GeorgeRenu George

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background & objectives: There have been very few community based studies on prevalence of hepatitis B virus (HBV) infection in India. We undertook this study to determine the prevalence of HBV infection in a southern State of India, Tamil Nadu and to describe the important factors related to transmission of the virus in the community. Methods: Analysis of stored blood samples from a representative population of Tamil Nadu from an earlier community cluster survey on sexually transmitted diseases (STD) prevalence using proportionate to population size (PPS) technique was done. Serum markers of HBV viz., hapatitis B surface antigen (HBsAg), hepatitis B e antigen (HBe Ag) and antibody to surface antigen (anti-HBs) were performed. Results: 1981 subjects were screened in the study. HBsAg prevalence was 5.7 per cent (CI 4.6-6.8) with 23.5 per cent (25/106) of these having positive HBe-antigen. Community seroprevalence (HbsAg + anti-HBs) of hepatitis B infection was 27.4 per cent (CI: 25.3-29.5) with the highest prevalence of 32.7 per cent (CI: 30.2-35.2) noted in the 15-20 yr age group. Significant independent association (OR 1.4; P=0.006) was detected with family history of exposure to HBV infection by logistic modeling. Other risk factors noted to have significant association were use of disposable needles during injection (OR 0.5; P=0.02) in men, smoking (OR 3; P=0.04) and use of condom (OR 0.6; P=0.08) in women. Interpretation & conclusion: This community based study shows a high prevalence of hepatitis B infection in the state of Tamil Nadu with the highest prevalence being in the younger (15-20 yr) age group. High prevalence rate in childhood with e-antigenemia seen in 23.5 per cent of HBsAg positive subjects suggest childhood transmission. Poor injection practices and high-risk sexual behavior were found to be additional risk factors for transmission of the disease in the community.

Original languageEnglish
Pages (from-to)670-675
Number of pages6
JournalIndian Journal of Medical Research
Volume121
Issue number5
Publication statusPublished - May 2005

Fingerprint

Hepatitis B
Viruses
India
Surface Antigens
Hepatitis B virus
Infection
Virus Diseases
Hepatitis B e Antigens
Age Groups
Antigens
Hepatitis B Antibodies
Needles
Logistics
Injections
Blood
Seroepidemiologic Studies
Condoms
Sexually Transmitted Diseases
Risk-Taking
Population Density

Keywords

  • Community
  • Hepatitis B infection
  • Mode of transmission
  • Prevalence
  • Tamil Nuda, India

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kurien, T., Thyagarajan, S. P., Jeyaseelan, L., Peedicayil, A., Rajendran, P., Sivaram, S., ... George, R. (2005). Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India. Indian Journal of Medical Research, 121(5), 670-675.

Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India. / Kurien, Thomas; Thyagarajan, S. P.; Jeyaseelan, L.; Peedicayil, A.; Rajendran, P.; Sivaram, S.; Hansdak, S. G.; Renu, G.; Krishnamurthy, P.; Sudhakar, K.; Varghese, K.; Joyee, A. G.; Hari, D.; Bai, Lakshmi; Srinivasan, Vijaya; Varghese, J. C.; Sethuraman Meenakshi, N.; Hira, S.; Gharpure, H.; George, Soshamma; George, Renu.

In: Indian Journal of Medical Research, Vol. 121, No. 5, 05.2005, p. 670-675.

Research output: Contribution to journalArticle

Kurien, T, Thyagarajan, SP, Jeyaseelan, L, Peedicayil, A, Rajendran, P, Sivaram, S, Hansdak, SG, Renu, G, Krishnamurthy, P, Sudhakar, K, Varghese, K, Joyee, AG, Hari, D, Bai, L, Srinivasan, V, Varghese, JC, Sethuraman Meenakshi, N, Hira, S, Gharpure, H, George, S & George, R 2005, 'Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India', Indian Journal of Medical Research, vol. 121, no. 5, pp. 670-675.
Kurien T, Thyagarajan SP, Jeyaseelan L, Peedicayil A, Rajendran P, Sivaram S et al. Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India. Indian Journal of Medical Research. 2005 May;121(5):670-675.
Kurien, Thomas ; Thyagarajan, S. P. ; Jeyaseelan, L. ; Peedicayil, A. ; Rajendran, P. ; Sivaram, S. ; Hansdak, S. G. ; Renu, G. ; Krishnamurthy, P. ; Sudhakar, K. ; Varghese, K. ; Joyee, A. G. ; Hari, D. ; Bai, Lakshmi ; Srinivasan, Vijaya ; Varghese, J. C. ; Sethuraman Meenakshi, N. ; Hira, S. ; Gharpure, H. ; George, Soshamma ; George, Renu. / Community prevalence of hepatitis B infection & modes of transmission in Tamil Nadu, India. In: Indian Journal of Medical Research. 2005 ; Vol. 121, No. 5. pp. 670-675.
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abstract = "Background & objectives: There have been very few community based studies on prevalence of hepatitis B virus (HBV) infection in India. We undertook this study to determine the prevalence of HBV infection in a southern State of India, Tamil Nadu and to describe the important factors related to transmission of the virus in the community. Methods: Analysis of stored blood samples from a representative population of Tamil Nadu from an earlier community cluster survey on sexually transmitted diseases (STD) prevalence using proportionate to population size (PPS) technique was done. Serum markers of HBV viz., hapatitis B surface antigen (HBsAg), hepatitis B e antigen (HBe Ag) and antibody to surface antigen (anti-HBs) were performed. Results: 1981 subjects were screened in the study. HBsAg prevalence was 5.7 per cent (CI 4.6-6.8) with 23.5 per cent (25/106) of these having positive HBe-antigen. Community seroprevalence (HbsAg + anti-HBs) of hepatitis B infection was 27.4 per cent (CI: 25.3-29.5) with the highest prevalence of 32.7 per cent (CI: 30.2-35.2) noted in the 15-20 yr age group. Significant independent association (OR 1.4; P=0.006) was detected with family history of exposure to HBV infection by logistic modeling. Other risk factors noted to have significant association were use of disposable needles during injection (OR 0.5; P=0.02) in men, smoking (OR 3; P=0.04) and use of condom (OR 0.6; P=0.08) in women. Interpretation & conclusion: This community based study shows a high prevalence of hepatitis B infection in the state of Tamil Nadu with the highest prevalence being in the younger (15-20 yr) age group. High prevalence rate in childhood with e-antigenemia seen in 23.5 per cent of HBsAg positive subjects suggest childhood transmission. Poor injection practices and high-risk sexual behavior were found to be additional risk factors for transmission of the disease in the community.",
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AU - Thyagarajan, S. P.

AU - Jeyaseelan, L.

AU - Peedicayil, A.

AU - Rajendran, P.

AU - Sivaram, S.

AU - Hansdak, S. G.

AU - Renu, G.

AU - Krishnamurthy, P.

AU - Sudhakar, K.

AU - Varghese, K.

AU - Joyee, A. G.

AU - Hari, D.

AU - Bai, Lakshmi

AU - Srinivasan, Vijaya

AU - Varghese, J. C.

AU - Sethuraman Meenakshi, N.

AU - Hira, S.

AU - Gharpure, H.

AU - George, Soshamma

AU - George, Renu

PY - 2005/5

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N2 - Background & objectives: There have been very few community based studies on prevalence of hepatitis B virus (HBV) infection in India. We undertook this study to determine the prevalence of HBV infection in a southern State of India, Tamil Nadu and to describe the important factors related to transmission of the virus in the community. Methods: Analysis of stored blood samples from a representative population of Tamil Nadu from an earlier community cluster survey on sexually transmitted diseases (STD) prevalence using proportionate to population size (PPS) technique was done. Serum markers of HBV viz., hapatitis B surface antigen (HBsAg), hepatitis B e antigen (HBe Ag) and antibody to surface antigen (anti-HBs) were performed. Results: 1981 subjects were screened in the study. HBsAg prevalence was 5.7 per cent (CI 4.6-6.8) with 23.5 per cent (25/106) of these having positive HBe-antigen. Community seroprevalence (HbsAg + anti-HBs) of hepatitis B infection was 27.4 per cent (CI: 25.3-29.5) with the highest prevalence of 32.7 per cent (CI: 30.2-35.2) noted in the 15-20 yr age group. Significant independent association (OR 1.4; P=0.006) was detected with family history of exposure to HBV infection by logistic modeling. Other risk factors noted to have significant association were use of disposable needles during injection (OR 0.5; P=0.02) in men, smoking (OR 3; P=0.04) and use of condom (OR 0.6; P=0.08) in women. Interpretation & conclusion: This community based study shows a high prevalence of hepatitis B infection in the state of Tamil Nadu with the highest prevalence being in the younger (15-20 yr) age group. High prevalence rate in childhood with e-antigenemia seen in 23.5 per cent of HBsAg positive subjects suggest childhood transmission. Poor injection practices and high-risk sexual behavior were found to be additional risk factors for transmission of the disease in the community.

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