Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association?

S. Sinha, L. K. Prashanth, A. Mahadevan, S. Satish, S. Ravishankar, G. R. Arunodaya, A. B. Taly, S. K. Shankar

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalClinical Neuropathology
Volume23
Issue number5
Publication statusPublished - Sep 2004

Fingerprint

Retinoblastoma Protein
Hepatolenticular Degeneration
Glioblastoma
Chromosomes, Human, Pair 13
Retinoblastoma
Mutation
Neoplasms

Keywords

  • Glioblastoma multiforme
  • Malignancy
  • p53
  • Rb protein
  • Wilson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Sinha, S., Prashanth, L. K., Mahadevan, A., Satish, S., Ravishankar, S., Arunodaya, G. R., ... Shankar, S. K. (2004). Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association? Clinical Neuropathology, 23(5), 241-244.

Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association? / Sinha, S.; Prashanth, L. K.; Mahadevan, A.; Satish, S.; Ravishankar, S.; Arunodaya, G. R.; Taly, A. B.; Shankar, S. K.

In: Clinical Neuropathology, Vol. 23, No. 5, 09.2004, p. 241-244.

Research output: Contribution to journalArticle

Sinha, S, Prashanth, LK, Mahadevan, A, Satish, S, Ravishankar, S, Arunodaya, GR, Taly, AB & Shankar, SK 2004, 'Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association?', Clinical Neuropathology, vol. 23, no. 5, pp. 241-244.
Sinha S, Prashanth LK, Mahadevan A, Satish S, Ravishankar S, Arunodaya GR et al. Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association? Clinical Neuropathology. 2004 Sep;23(5):241-244.
Sinha, S. ; Prashanth, L. K. ; Mahadevan, A. ; Satish, S. ; Ravishankar, S. ; Arunodaya, G. R. ; Taly, A. B. ; Shankar, S. K. / Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association?. In: Clinical Neuropathology. 2004 ; Vol. 23, No. 5. pp. 241-244.
@article{8e9eb0f1805a4db18fe424a5f86db479,
title = "Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association?",
abstract = "We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60{\%}) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.",
keywords = "Glioblastoma multiforme, Malignancy, p53, Rb protein, Wilson's disease",
author = "S. Sinha and Prashanth, {L. K.} and A. Mahadevan and S. Satish and S. Ravishankar and Arunodaya, {G. R.} and Taly, {A. B.} and Shankar, {S. K.}",
year = "2004",
month = "9",
language = "English",
volume = "23",
pages = "241--244",
journal = "Clinical Neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "5",

}

TY - JOUR

T1 - Co-occurrence of Wilson's disease and glioblastoma multiforme - Is it a chance association?

AU - Sinha, S.

AU - Prashanth, L. K.

AU - Mahadevan, A.

AU - Satish, S.

AU - Ravishankar, S.

AU - Arunodaya, G. R.

AU - Taly, A. B.

AU - Shankar, S. K.

PY - 2004/9

Y1 - 2004/9

N2 - We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.

AB - We report a patient with glioblastoma multiforme who was subsequently diagnosed to have Wilson's disease. Immunohistochemical studies of the tumor revealed high (> 60%) labeling index for p53 and Rb retinoblastoma protein. Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored.

KW - Glioblastoma multiforme

KW - Malignancy

KW - p53

KW - Rb protein

KW - Wilson's disease

UR - http://www.scopus.com/inward/record.url?scp=4544275228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4544275228&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 241

EP - 244

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 5

ER -