Clinical profile of myasthenia gravis in the Sultanate of Oman

Poovathoor C. Jacob, John T. Tharakan, Pratap R. Chand, Roshan L. Koul, Alexander P. Chacko

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Abstract

Objective: Clinical study and follow up of myasthenia gravis patients in Oman. Methods: Follow up of 50 consecutive myasthenia gravis patients referred to the Sultan Qaboos University Hospital, Oman for a median period of 3 years from 1997 to 2000. We based the diagnosis on the clinical picture, repetitive nerve stimulation tests and edrophonium test. We performed a computerized tomography scan of the chest and anti-acetylcholine receptor antibodies. We reviewed the results of immuno modulatory treatment including thymectomy and compared these with other studies. Results: Of 50 patients, 6 had purely ocular myasthenia. Of the 44 with generalized myasthenia, 28 had bulbar involvement and 12 required ventilatory support. Eight out of 29 thymectomized patients had drug free remission after 2 years. There was worsening of myasthenic symptoms in only one out of 8 pregnancies and deliveries. Conclusions: Bulbar and ventilatory involvement are more common in our series as compared with western data. Pregnancy and delivery were well tolerated.

Original languageEnglish
Pages (from-to)774-775
Number of pages2
JournalSaudi Medical Journal
Volume24
Issue number7
Publication statusPublished - Jul 1 2003

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ASJC Scopus subject areas

  • Medicine(all)

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Jacob, P. C., Tharakan, J. T., Chand, P. R., Koul, R. L., & Chacko, A. P. (2003). Clinical profile of myasthenia gravis in the Sultanate of Oman. Saudi Medical Journal, 24(7), 774-775.