TY - JOUR
T1 - Clinical features of Behçet's disease in patients in the Sultanate of Oman; the significance of antiphospholipid antibodies?
AU - El-Ageb, E. M.
AU - Al-Maini, M. H.
AU - Al-Shukaily, A. K.
AU - Al-Farsi, Y.
AU - Richens, E. R.
N1 - Funding Information:
Ethics permission for this study was granted by the Medical Research and Ethics Committee of the College of Medicine, Sultan Qaboos University, Sultanate of Oman. The study was carried out in accordance with the Treaty of Helsinki.
PY - 2002
Y1 - 2002
N2 - The prevalence of symptoms in 34 Omani patients with Behçet's disease (BD) was: recurrent oral ulceration 100%, arthritis/arthralgia and genital ulceration 74% each, folliculitis 64%, neurological lesions 62%, retinal vasculitis 30%, iritis and hypopyon 26%, gastrointestinal lesions 12%, venous thrombosis and cardiovascular lesions 9% each, and pleuropulmonary lesions and epididymitis 6% each. Antiphospholipid (APL) antibodies (both anticardiolipin [ACAs] and anti-β2 glycoprotein I [aβ2GPIs]) were present in 11/34 (32%) of the BD patients and in 54/73 (74%) of Omani patients with systemic lupus erythematosus (SLE) (x2=21.2, P<0.001). In patients possessing APL antibodies, there was no significant difference in mean antibody levels between BD and SLE patients. IgM isotype antibodies, in the absence of IgG, were more prevalent in BD (5/11) than in SLE (10/54) patients (x2=3.8, P=0.05). The frequency of organ involvement was similar in patients with and without APL antibodies (x2=1.226, P>0.05). This study fails to demonstrate a pathognomonic role for APL antibodies in BD.
AB - The prevalence of symptoms in 34 Omani patients with Behçet's disease (BD) was: recurrent oral ulceration 100%, arthritis/arthralgia and genital ulceration 74% each, folliculitis 64%, neurological lesions 62%, retinal vasculitis 30%, iritis and hypopyon 26%, gastrointestinal lesions 12%, venous thrombosis and cardiovascular lesions 9% each, and pleuropulmonary lesions and epididymitis 6% each. Antiphospholipid (APL) antibodies (both anticardiolipin [ACAs] and anti-β2 glycoprotein I [aβ2GPIs]) were present in 11/34 (32%) of the BD patients and in 54/73 (74%) of Omani patients with systemic lupus erythematosus (SLE) (x2=21.2, P<0.001). In patients possessing APL antibodies, there was no significant difference in mean antibody levels between BD and SLE patients. IgM isotype antibodies, in the absence of IgG, were more prevalent in BD (5/11) than in SLE (10/54) patients (x2=3.8, P=0.05). The frequency of organ involvement was similar in patients with and without APL antibodies (x2=1.226, P>0.05). This study fails to demonstrate a pathognomonic role for APL antibodies in BD.
KW - Antiphospholipid antibodies
KW - Behçet's disease
KW - Clinical symptom
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U2 - 10.1007/s00296-001-0157-8
DO - 10.1007/s00296-001-0157-8
M3 - Article
C2 - 11958433
AN - SCOPUS:0036192814
SN - 0172-8172
VL - 21
SP - 176
EP - 181
JO - Rheumatology International
JF - Rheumatology International
IS - 5
ER -