Circadian rhythm and the immune response

A review

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

For long, the immune system has been thought of as an effector mechanism reacting to antigenic challenge with defensive responses designed to eliminate 'foreign' material and return to a standby or surveillance mode. However, the recent concept now supported by substantial evidence suggests that immunity is not effector biased but is also a sensory organ and forms part of an integrated homeostatic network. The bidirectional information flow between the neuroendocrine and immune systems functions to maintain and protect the internal homeostasis of the organism. The paradox of this interwined function is that homeostasis may require the neuroendocrine system to work for or against the immune system, as is the case in infection. Potential dangers necessitate activation of the immune system, and such a response may pose risks to the integrity of the host. This occurs when an overly vigorous response may be detrimental and kill the host, as is the case of toxic shock syndrome. Therefore, the constant monitoring role of the neuroendocrine system to control and, when necessary, regulate the function of the immune system is crucial for the homeostatic integrity of the host. This reciprocity of functional need determines the mode of action to determine the context of a perceived threat and the best way to respond. Any breakdown in this two-way communication may manifest itself in problems such as autoimmunity, septic shock, or chronic infection. In this article, we review our current knowledge of circadian rhythm and its relation to the immune response.

Original languageEnglish
Pages (from-to)93-108
Number of pages16
JournalInternational Reviews of Immunology
Volume28
Issue number1-2
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Circadian Rhythm
Immune System
Neurosecretory Systems
Septic Shock
Homeostasis
Infection
Autoimmunity
Immunity

Keywords

  • Circadian rhythm
  • Immune response
  • Immunity
  • Neuroendocrine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Circadian rhythm and the immune response : A review. / Habbal, O. A.; Al-Jabri, A. A.

In: International Reviews of Immunology, Vol. 28, No. 1-2, 02.2009, p. 93-108.

Research output: Contribution to journalArticle

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