Chronic verapamil administration alters phenytoin pharmacokinetics in the rat

M. O M Tanira; I. A. Wasfi; A. K. Bashir; D. W G Harron

doi:10.1016/0378-5173(94)90065-5

Chronic verapamil administration alters phenytoin pharmacokinetics in the rat

M. O M Tanira^*, I. A. Wasfi, A. K. Bashir, D. W G Harron

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.

Original language	English
Pages (from-to)	267-269
Number of pages	3
Journal	International Journal of Pharmaceutics
Volume	102
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(94)90065-5
Publication status	Published - Feb 7 1994

Keywords

Pharmacokinetics
Phenytoin
Rat
Verapamil

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/0378-5173(94)90065-5

Cite this

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title = "Chronic verapamil administration alters phenytoin pharmacokinetics in the rat",

abstract = "The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.",

keywords = "Pharmacokinetics, Phenytoin, Rat, Verapamil",

author = "Tanira, {M. O M} and Wasfi, {I. A.} and Bashir, {A. K.} and Harron, {D. W G}",

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AU - Tanira, M. O M

AU - Wasfi, I. A.

AU - Bashir, A. K.

AU - Harron, D. W G

PY - 1994/2/7

Y1 - 1994/2/7

N2 - The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.

AB - The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.

KW - Pharmacokinetics

KW - Phenytoin

KW - Rat

KW - Verapamil

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Chronic verapamil administration alters phenytoin pharmacokinetics in the rat

Abstract

Keywords

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