Abstract
The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 267-269 |
| Number of pages | 3 |
| Journal | International Journal of Pharmaceutics |
| Volume | 102 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Feb 7 1994 |
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Keywords
- Pharmacokinetics
- Phenytoin
- Rat
- Verapamil
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Chronic verapamil administration alters phenytoin pharmacokinetics in the rat. / Tanira, M. O M; Wasfi, I. A.; Bashir, A. K.; Harron, D. W G.
In: International Journal of Pharmaceutics, Vol. 102, No. 1-3, 07.02.1994, p. 267-269.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chronic verapamil administration alters phenytoin pharmacokinetics in the rat
AU - Tanira, M. O M
AU - Wasfi, I. A.
AU - Bashir, A. K.
AU - Harron, D. W G
PY - 1994/2/7
Y1 - 1994/2/7
N2 - The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.
AB - The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.
KW - Pharmacokinetics
KW - Phenytoin
KW - Rat
KW - Verapamil
UR - http://www.scopus.com/inward/record.url?scp=0027953640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027953640&partnerID=8YFLogxK
U2 - 10.1016/0378-5173(94)90065-5
DO - 10.1016/0378-5173(94)90065-5
M3 - Article
VL - 102
SP - 267
EP - 269
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1-3
ER -