Chronic verapamil administration alters phenytoin pharmacokinetics in the rat

M. O M Tanira, I. A. Wasfi, A. K. Bashir, D. W G Harron

Research output: Contribution to journalArticle

Abstract

The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.

Original languageEnglish
Pages (from-to)267-269
Number of pages3
JournalInternational Journal of Pharmaceutics
Volume102
Issue number1-3
DOIs
Publication statusPublished - Feb 7 1994

Keywords

  • Pharmacokinetics
  • Phenytoin
  • Rat
  • Verapamil

ASJC Scopus subject areas

  • Pharmaceutical Science

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