Abstract
The interaction of verapamil (4 and 8 mg/kg twice daily for 7 days) and i.v. phenytoin (10 mg/kg) in male Wistar rats has been studied. Increases occurred in phenytoin plasma elimination half-life (61%; p < 0.01 and 80%; p < 0.05), the area under the plasma concentration curve (32% n.s. and 48; p < 0.05) and volume of distribution (17%; p < 0.05 and 14% n.s.) after 4 and 8 mg/kg verapamil, respectively. The clearance was reduced to 75% (n.s.) and 67% (p < 0.05) of the control value; changes were not dose-dependent.
| Original language | English |
|---|---|
| Pages (from-to) | 267-269 |
| Number of pages | 3 |
| Journal | International Journal of Pharmaceutics |
| Volume | 102 |
| Issue number | 1-3 |
| DOIs | |
| Publication status | Published - Feb 7 1994 |
Keywords
- Pharmacokinetics
- Phenytoin
- Rat
- Verapamil
ASJC Scopus subject areas
- Pharmaceutical Science
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Tanira, M. O. M., Wasfi, I. A., Bashir, A. K., & Harron, D. W. G. (1994). Chronic verapamil administration alters phenytoin pharmacokinetics in the rat. International Journal of Pharmaceutics, 102(1-3), 267-269. https://doi.org/10.1016/0378-5173(94)90065-5