Chemometric optimization and flow injection method for the determination of norfloxacin in drug formulations

Salah M. Sultan; Fakhr Eldin O. Suliman

doi:10.1039/AN9931800573

Chemometric optimization and flow injection method for the determination of norfloxacin in drug formulations

Salah M. Sultan^*, Fakhr Eldin O. Suliman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A flow injection spectrophotometric method for the determination of the antibiotic norfloxacin in drug formulations in the range 50-450 ppm was developed. Iron(III) was employed to produce a coloured complex absorbing at 430 nm in sulfuric acid medium. A factorial design program was utilized to establish the highly interacting factors that must be optimized. Optimization was carried out by the super modified simplex method. The optimum conditions were 0.043 mol dm^-3 sulfuric acid, 0.0271 mol dm^-3 iron(III), flow rate 5.33 cm³ min^-1, sample size 210 mm³ and coil length 45 cm. A sampling frequency of 140 h^-1 was attained.

Original language	English
Pages (from-to)	573-576
Number of pages	4
Journal	The Analyst
Volume	118
Issue number	5
DOIs	https://doi.org/10.1039/AN9931800573
Publication status	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Environmental Chemistry
Spectroscopy
Electrochemistry

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abstract = "A flow injection spectrophotometric method for the determination of the antibiotic norfloxacin in drug formulations in the range 50-450 ppm was developed. Iron(III) was employed to produce a coloured complex absorbing at 430 nm in sulfuric acid medium. A factorial design program was utilized to establish the highly interacting factors that must be optimized. Optimization was carried out by the super modified simplex method. The optimum conditions were 0.043 mol dm-3 sulfuric acid, 0.0271 mol dm-3 iron(III), flow rate 5.33 cm3 min-1, sample size 210 mm3 and coil length 45 cm. A sampling frequency of 140 h-1 was attained.",

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AU - Suliman, Fakhr Eldin O.

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AB - A flow injection spectrophotometric method for the determination of the antibiotic norfloxacin in drug formulations in the range 50-450 ppm was developed. Iron(III) was employed to produce a coloured complex absorbing at 430 nm in sulfuric acid medium. A factorial design program was utilized to establish the highly interacting factors that must be optimized. Optimization was carried out by the super modified simplex method. The optimum conditions were 0.043 mol dm-3 sulfuric acid, 0.0271 mol dm-3 iron(III), flow rate 5.33 cm3 min-1, sample size 210 mm3 and coil length 45 cm. A sampling frequency of 140 h-1 was attained.

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Chemometric optimization and flow injection method for the determination of norfloxacin in drug formulations

Abstract

ASJC Scopus subject areas

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