Chemometric optimization and flow injection method for the determination of norfloxacin in drug formulations

Salah M. Sultan, Fakhr Eldin O Suliman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A flow injection spectrophotometric method for the determination of the antibiotic norfloxacin in drug formulations in the range 50-450 ppm was developed. Iron(III) was employed to produce a coloured complex absorbing at 430 nm in sulfuric acid medium. A factorial design program was utilized to establish the highly interacting factors that must be optimized. Optimization was carried out by the super modified simplex method. The optimum conditions were 0.043 mol dm-3 sulfuric acid, 0.0271 mol dm-3 iron(III), flow rate 5.33 cm3 min-1, sample size 210 mm3 and coil length 45 cm. A sampling frequency of 140 h-1 was attained.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalAnalyst
Volume118
Issue number5
DOIs
Publication statusPublished - 1993

Fingerprint

Norfloxacin
Drug Compounding
Sulfuric acid
sulfuric acid
drug
Iron
iron
Injections
Antibiotics
antibiotics
Sample Size
Flow rate
Sampling
Anti-Bacterial Agents
sampling
method
Pharmaceutical Chemistry
rate
programme

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Chemometric optimization and flow injection method for the determination of norfloxacin in drug formulations. / Sultan, Salah M.; Suliman, Fakhr Eldin O.

In: Analyst, Vol. 118, No. 5, 1993, p. 573-576.

Research output: Contribution to journalArticle

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