Chemiluminescence of bovine alveolar macrophages as an indicator of developing immunity in calves vaccinated with aromatic-dependent Salmonella

Eugene H. Johnson, Sharon Hietala, Bradford P. Smith

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chemiluminescence of bovine alveolar macrophages was used to study the development of opsonins in calves vaccinated parenterally with live aromatic-dependent strains of either S. dublin or S. typhimurium. These calves responded by producing Salmonella-specific opsonins detected by increased chemiluminescent responses, and were able to survive oral challenge with live virulent organisms of either serotype. Non-vaccinated calves of the same age lacked Salmonella-specific opsonins and were not able to survive challenge. Thus it was concluded that the ability to produce opsonins is among the immunological responses that are associated with protection against salmonellosis in calves. Antigenic similarities between S. dublin and S. typhimurium were shown by the ability of either organism to absorb significant amounts of opsonic capacity from the sera of calves vaccinated with either of the two vaccines. These antigenic similarities are thought to explain in part the ability of either vaccine to protect against challenge with either the homologous or heterologous Salmonella serotype.

Original languageEnglish
Pages (from-to)451-464
Number of pages14
JournalVeterinary Microbiology
Volume10
Issue number5
DOIs
Publication statusPublished - 1985

Fingerprint

Opsonin Proteins
opsonins
chemiluminescence
Alveolar Macrophages
Luminescence
Salmonella
aromatic compounds
Immunity
macrophages
immunity
calves
cattle
Vaccines
serotypes
Salmonella Infections
vaccines
organisms
salmonellosis
mouth
immune response

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Microbiology
  • veterinary(all)

Cite this

Chemiluminescence of bovine alveolar macrophages as an indicator of developing immunity in calves vaccinated with aromatic-dependent Salmonella. / Johnson, Eugene H.; Hietala, Sharon; Smith, Bradford P.

In: Veterinary Microbiology, Vol. 10, No. 5, 1985, p. 451-464.

Research output: Contribution to journalArticle

@article{180135c85b614d8ea58f848fd8a55599,
title = "Chemiluminescence of bovine alveolar macrophages as an indicator of developing immunity in calves vaccinated with aromatic-dependent Salmonella",
abstract = "Chemiluminescence of bovine alveolar macrophages was used to study the development of opsonins in calves vaccinated parenterally with live aromatic-dependent strains of either S. dublin or S. typhimurium. These calves responded by producing Salmonella-specific opsonins detected by increased chemiluminescent responses, and were able to survive oral challenge with live virulent organisms of either serotype. Non-vaccinated calves of the same age lacked Salmonella-specific opsonins and were not able to survive challenge. Thus it was concluded that the ability to produce opsonins is among the immunological responses that are associated with protection against salmonellosis in calves. Antigenic similarities between S. dublin and S. typhimurium were shown by the ability of either organism to absorb significant amounts of opsonic capacity from the sera of calves vaccinated with either of the two vaccines. These antigenic similarities are thought to explain in part the ability of either vaccine to protect against challenge with either the homologous or heterologous Salmonella serotype.",
author = "Johnson, {Eugene H.} and Sharon Hietala and Smith, {Bradford P.}",
year = "1985",
doi = "10.1016/0378-1135(85)90027-6",
language = "English",
volume = "10",
pages = "451--464",
journal = "Veterinary Microbiology",
issn = "0378-1135",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Chemiluminescence of bovine alveolar macrophages as an indicator of developing immunity in calves vaccinated with aromatic-dependent Salmonella

AU - Johnson, Eugene H.

AU - Hietala, Sharon

AU - Smith, Bradford P.

PY - 1985

Y1 - 1985

N2 - Chemiluminescence of bovine alveolar macrophages was used to study the development of opsonins in calves vaccinated parenterally with live aromatic-dependent strains of either S. dublin or S. typhimurium. These calves responded by producing Salmonella-specific opsonins detected by increased chemiluminescent responses, and were able to survive oral challenge with live virulent organisms of either serotype. Non-vaccinated calves of the same age lacked Salmonella-specific opsonins and were not able to survive challenge. Thus it was concluded that the ability to produce opsonins is among the immunological responses that are associated with protection against salmonellosis in calves. Antigenic similarities between S. dublin and S. typhimurium were shown by the ability of either organism to absorb significant amounts of opsonic capacity from the sera of calves vaccinated with either of the two vaccines. These antigenic similarities are thought to explain in part the ability of either vaccine to protect against challenge with either the homologous or heterologous Salmonella serotype.

AB - Chemiluminescence of bovine alveolar macrophages was used to study the development of opsonins in calves vaccinated parenterally with live aromatic-dependent strains of either S. dublin or S. typhimurium. These calves responded by producing Salmonella-specific opsonins detected by increased chemiluminescent responses, and were able to survive oral challenge with live virulent organisms of either serotype. Non-vaccinated calves of the same age lacked Salmonella-specific opsonins and were not able to survive challenge. Thus it was concluded that the ability to produce opsonins is among the immunological responses that are associated with protection against salmonellosis in calves. Antigenic similarities between S. dublin and S. typhimurium were shown by the ability of either organism to absorb significant amounts of opsonic capacity from the sera of calves vaccinated with either of the two vaccines. These antigenic similarities are thought to explain in part the ability of either vaccine to protect against challenge with either the homologous or heterologous Salmonella serotype.

UR - http://www.scopus.com/inward/record.url?scp=0021808263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021808263&partnerID=8YFLogxK

U2 - 10.1016/0378-1135(85)90027-6

DO - 10.1016/0378-1135(85)90027-6

M3 - Article

VL - 10

SP - 451

EP - 464

JO - Veterinary Microbiology

JF - Veterinary Microbiology

SN - 0378-1135

IS - 5

ER -